.Your missionThe Josep Carreras Leukaemia Research Institute (IJC) is a non-profit research institute based in Barcelona and dedicated to advancing our understanding about leukaemia and related disorders, in partnership with the University of Barcelona and University Autònoma of Barcelona.The IJC has laboratories in three clinical campuses: i) Clinic Hospital, ii) Sant Pau Hospital, and iii) Germans Trias i Pujol Hospital.IJC serves as a collaborative hub for basic investigators and physicians to work together on fundamental biological and clinical aspects of leukaemia.The IJC offers an excellent work environment built around a multi-disciplinary fusion of ideas and state-of-the-art facilities.Your profileResearch DescriptionThe Cuartero lab is seeking a highly motivated postdoctoral researcher to join our team. We investigate the mechanisms that regulate transcription in normal blood development and leukemia.Acute myeloid leukemia (AML) is one of the most aggressive forms of leukemia, and there is an urgent need for new treatment options.Although the genes recurrently mutated in AML are known, the reasons these mutations drive malignancy remain unclear. Our research aims to address the following questions:What transcriptional mechanisms are deregulated in acute myeloid leukemia?How do inflammatory signals influence leukemic progression?Can inflammatory modulation attenuate the severity of myeloid malignancies?Our previous work has demonstrated that alterations in enhancer-promoter contacts and three-dimensional genome organization are critical drivers of leukemia. We are now focused on identifying additional proteins involved in these processes.We encourage applications from highly motivated scientists with a strong interest in epigenetics, hematopoiesis, or leukemia.This position is part of the grant PID2023-151180OB-I00, and it is funded by MCIU / AEI / 10.13039 / 501100011033 and for FSE+.Please send your CV, contact information for referees, and any informal inquiries to [email protected]What we needA high level of motivation and interest.PhD degree in life sciences or similar.Strong background in experimental molecular biology and experience with mouse models.A demonstrated ability to work collaboratively and effectively within a team is also essential.What we offerThree years full-funded position.Working in the mixed basic and clinical research environment of the Josep Carreras Leukaemia Research Institute.Incorporation in a multinational and highly collaborative team.The stimulating environment of the Barcelona metropolitan area.Deadline for ApplicationsPlease submit your application by 30 October 2024.About usThe mission of the Josep Carreras Institute is to conduct research and drive innovation in the epidemiological, preventive, clinical, translational, and basic aspects of cancer, with a special emphasis on leukaemia and other hematologic malignancies, with the final aim of finding a cure for these diseases
