Postdoc - Gene Regulation In Hematopoiesis - Ng-730

The Institute: The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed of an interdisciplinary, motivated, and creative scientific team supported by a flexible and efficient administration and high-end innovative technologies.The Single Cell and Synthetic Genomics of Blood Formation lab (PI: Lars Velten) at CRG Barcelona is looking for a motivated computational or mixed computational-experimental postdoc to use synthetic enhancers, CRISPR screening, and computational approaches to unravel the logic of gene regulation in blood stem cell differentiation.Blood formation is an essential, biomedically relevant, and complex process of cellular differentiation. Our group studies adult hematopoiesis using computational biology, single cell genomics, and genetic screens. In the past four years, we have established a research line using fully synthetic DNA constructs to understand how hematopoietic stem cells transform continuous transcription factor gradients into cell state-specific gene expression patterns and to engineer artificial, cell state-specific hematopoietic enhancers from scratch.In your new role, you would:Develop a project on gene regulation in the blood-forming system.Analyze data from synthetic enhancer MPRA screens, single cell MPRA screens, and dual MPRA-CRISPR screens.Design experiments using these technologies and collaborate with an experienced technician to implement these experiments.Interact closely with both wetlab and computational scientists from the group.Serve as a senior member of the team and, down the road, co-supervisor of PhD students or technical staff.Your work would be part of the project "Artificial Intelligence for Synthetic Genomics of Blood," funded with a prestigious ERC Starting Grant. A 45-second video summary of that grant is available online.About the lab: My interdisciplinary group investigates the biology of hematopoietic stem cells using a combination of single cell genomics, genetic screens, and computational biology. We strive to develop novel genomic and bioinformatic tools to answer longstanding questions in the field. In particular, we cover two main research lines: a) Gene regulation in healthy hematopoiesis and b) Clonal function in ageing and disease. The lab has been established in January 2020 and currently consists of six members: two PhD students, two bridging postdocs, one postdoc, and two senior technicians.#J-18808-Ljbffr