Research Technician: Prostate Cancer Pdx Models And In-Vivo Experiments

.The Vall d ´Hebron Institute of Oncology (VHIO) seeks a Research Technician: Prostate Cancer PDX models and In-Vivo experimentsReference: 2024-55-01Application deadline: 05/10/2024Number of vacancies: 1Job description:The Prostate Cancer Translational Research Group is seeking a Research Technician to join our lab.Our group mission is to improve advanced prostate cancer management through a better understanding of tumour response and resistance mechanisms and by correlating clinical and molecular data to advance towards a more precise patient care. Our multidisciplinary team is composed of biomedical scientists, bioinformaticians, medical oncologists, and clinical data specialists. Over the last few years, our team has established a collection of patient-derived xenograft models from patient tumor biopsies, which we now use for in-vivo experiments studying mechanisms of tumor sensitivity and resistance to different therapeutic approaches for prostate cancer.The successful candidate will form an integral part of our group. The position will include support for scientific training when required and opportunities to participate and lead new projects.Responsibilities:Maintenance and expansion of our cohort of patient-derived xenograft (PDX) and cell-line derived xenograft prostate cancer mice models.Design mouse surgeries, implanting human tumors or cell lines into mice (subcutaneous and orthotopically), monitor them and conduct sequential passages.Perform in vivo experiments and cellular biology techniques to support lab projects as well as projects in collaboration with pharmaceutical companies testing new drugs in our in vivo models.Research activities may include (but are not limited to) in vivo drug administration (oral gavage, IP administration), other minor surgeries (orchiectomy), and tissue processing.Involved in the histological and genomic characterization of all generated patient-derived models in collaboration with other group members.Committed to learning new techniques and concepts and contributing with new ideas on topics related to the lab's research goals.Requirements:Prior experience working with laboratory mouse models in the field of cancer research.Full accreditation for working with mice models in Spain.Organized, pro-active, team-oriented individual able to coordinate and perform multiple tasks.What we offer:The possibility of developing your professional career in a competitive environment.To be part of a centre that is constantly developing, pursuing excellence in research and collaborating with leading teams.A diverse and inclusive environment, welcoming all people equally, regardless of age, disability, gender, nationality, race, religion, or sexual orientation.Working conditions:Full-time position.Salary will be estimated according to profile and experience.Start date: October 2024.Flexible working hours and measures to reconcile work, family, personal life, and gender equality, as stipulated in the VHIO agreement