The Institute The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed of an interdisciplinary, motivated and creative scientific team supported by a flexible and efficient administration and high-end and innovative technologies.
In April 2021, the Centre for Genomic Regulation (CRG) received the renewal of the 'HR Excellence in Research' Award from the European Commission. This recognition reflects the Institute's commitment to developing an HR Strategy for Researchers, aligning practices and procedures with the principles of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers (Charter and Code).
Please check out our Recruitment Policy.
The Role This is a Postdoc position to study the role of X-chromosome inactivation for oocyte development in vitro from mouse embryonic stem cells. In a previous study (Severino et al., EMBO J 2022), we found evidence that X-inactivation is critical for meiotic and oogeneic potential. In this project, we aim to test this directly and gain insight into the mechanism of this phenomenon. The role involves bringing this ongoing project to completion and publication.
This position will continue the work of Bernhard Payer but will be incorporated into the Tissue Engineering Facility.
About the Labs The Payer lab is focused on elucidating the mechanisms of epigenetic reprogramming during embryogenesis, in pluripotent stem cells, and in the germ cell lineage. One particular topic of interest is the dramatic remodeling of the mammalian X chromosome in females from an inactive to an active state during a process called X-chromosome reactivation. We apply a multitude of in vivo and in vitro model systems to interrogate this process and its link to pluripotency and germ cell development. The work environment at the CRG consists of a dynamic, international research institute in Barcelona (Spain), where English is the working language.
The Tissue Engineering Unit is a scientific-technological core technology within the Core Technologies Programme. The goal of the Tissue Engineering Unit is to provide CRG, PRBB, and external researchers with the latest technologies used in the fields of stem cell biology, stem cell differentiation, organoid formation, induced pluripotent stem cells (iPSCs), and CRISPR/Cas9 gene editing. Established 8 years ago, the Unit aims to assist the research community in performing Stem Cell and Organoid projects to increase their impact. The Unit is constantly setting up new technologies emerging in these fields.
Whom Would We Like to Hire? Professional Experience Must Have You have at least 4 years of experience in mouse ESC culture and advanced in vitro differentiation models.
You have proven experience in Molecular Biology assays such as PCR and cloning, IF, Microscopy, FACS, single-cell RNA-Seq, DNA-methylation analysis, R-programming.
Theoretical background in Stem cells, Organoids, and Epigenetics.
Desirable but Not Required/Nice to Have Experience with Cut&Run or ChIP-Seq.
Education and Training You hold a PhD in the Stem cell and epigenetics field.
Languages You are fluent in English.
Technical Skills MS Office, Google Docs, Adobe Illustrator / Photoshop / Affinity designer or equivalent, R.
Mammalian Cell culture.
Competences Highly developed organizational skills.
The Offer – Working Conditions Contract Duration: 6 months.
Estimated Annual Gross Salary: Salary is commensurate with qualifications and consistent with our pay scales.
Target Start Date: 01.01.2025.
We provide a highly stimulating environment with state-of-the-art infrastructures and unique professional career development opportunities. To check out our training and development portfolio, please visit our website in the training section.
We offer and promote a diverse and inclusive environment and welcome applicants regardless of age, disability, gender, nationality, ethnicity, religion, sexual orientation, or gender identity.
The CRG is committed to reconciling work and family life for its employees and offers extended vacation periods and the possibility to benefit from flexible working hours.
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