The Institute The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed of an interdisciplinary, motivated and creative scientific team supported by a flexible and efficient administration and high-end innovative technologies.
In April 2021, the CRG received the renewal of the 'HR Excellence in Research' Award from the European Commission. This is a recognition of the Institute's commitment to developing an HR Strategy for Researchers, designed to align practices and procedures with the principles of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers.
The role Alternative splicing (AS) is the important process that allows the production of different messenger RNAs and proteins from a single gene in humans and other complex organisms. AS plays a crucial role in mechanisms controlling gene expression. Mutations affecting AS contribute to the development of many diseases, including cancer and neurodegeneration. While drugs that target AS have recently entered the clinic, there is still much to be learned about the mechanisms controlling splicing and their modulation by small molecules. The role of the PhD to be hired will be to contribute to the characterization of molecular mechanisms of AS regulation, including the identification and analysis of small molecule modulators and their possible applications in medicine.
About the team The group of Juan Valcárcel at the CRG has a long trajectory studying pre-mRNA splicing regulation. The group combines high-throughput methods with detailed biochemical and cellular assays and collaborates closely with other groups working on computational and structural biology to study molecular mechanisms and networks of alternative splicing regulation in cancer. The group also develops mechanism-based novel therapeutic approaches for oncology. Juan Valcárcel obtained his PhD from work on influenza virus splicing regulation at the Center of Molecular Biology Severo Ochoa in Madrid. After a postdoc with Michael Green at the University of Massachusetts, he established his group at the European Molecular Biology Laboratory (EMBL) in Heidelberg in 1996. In 2002, the group moved to the CRG of Barcelona. He is a Research Professor of the Catalonian Institute for Research and Advanced Studies (ICREA) and an associated Professor of the University Pompeu Fabra. Elected EMBO member in 2004, he was Deputy Coordinator of the European Alternative Splicing Network of Excellence and Coordinator of various European projects. He served as President of the RNA Society in 2017-2018 and as Past-President in 2019-2020. Our team currently consists of 2 technicians, 1 lab manager, 2 PhD students, 5 postdocs, and 1 Staff Scientist.
Whom would we like to hire? Professional experience Must Have You have a University Degree and a master's in molecular biology or a related discipline within the European Higher Education System (minimum 300 ECTS) or equivalent by October 2024.
You have hands-on experience in Molecular Biology and Gene Regulation.
Desirable but not required/ Nice to have Computational Biology Skills.
Experience with RNA analysis.
Education and training You have a University Degree and a master's in molecular biology or a related discipline within the European Higher Education System (minimum 300 ECTS) or equivalent by October 2024.
Languages You are proficient in English.
Technical skills You have advanced MS Office skills.
Competences Highly developed organizational skills.
Independence.
Professional ambition.
Capacity for teamwork.
The Offer – Working Conditions Contract duration: 4 years.
Estimated annual gross salary: Salary is commensurate with qualifications and consistent with our pay scales.
Target start date: January 2025.
We provide a highly stimulating environment with state-of-the-art infrastructures and unique professional career development opportunities. To check out our training and development portfolio, please visit our website in the training section.
We offer and promote a diverse and inclusive environment and welcome applicants regardless of age, disability, gender, nationality, ethnicity, religion, sexual orientation, or gender identity.
The CRG is committed to reconciling work and family life of its employees and offers an extended vacation period and the possibility to benefit from flexible working hours.
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