Associate Principal Physician Scientist, GenomicsLocation: Barcelona, Spain; Warsaw, PolandCompetitive Salary & BenefitsMake a more meaningful impact to patients' lives around the globeHere you'll have the opportunity to make a meaningful difference to patients' lives. With science at its heart, this is the place where breakthroughs born in the lab become transformative medicines – for the world's most complex diseases. Answer unmet medical needs by pioneering the next wave of science, focusing on outcomes and shaping the patient ecosystem.With our ground-breaking pipeline, the outlook is bright. Be proud to be part of a place that has achieved so much, yet is still moving forward. There's no better time to join our global, growing enterprise as we lead the way for healthcare and society.What You'll doAstraZeneca's Centre for Genomics Research (CGR) is currently seeking a physician with a research background to join our dedicated team focused on the company-wide Genomics Initiative which includes the analysis of up to 2 million genomes. In this role, you will apply your medical knowledge to help interpret DNA and multi-omics research data from AstraZeneca's clinical trials and broad biobanks representing ancestry diverse populations. Furthermore, you will play a pivotal role in leading deep-phenotyping and cohort stratification efforts aimed to further improve opportunities of identifying and validating new therapeutic targets for drug development. You will also contribute to the harmonization of healthcare records collected from a diverse range of geographical regions, an essential activity for maintaining data consistency and reliability in our research efforts.The successful candidate will work with leaders in human genomics delivering innovative science to genome analytics. You will also work closely with experts in translational science, drug discovery, pre-clinical modelling, and clinical development; thus, contributing to the broader objectives and success of the company-wide Genomics Initiative. This unique role requires an individual who is innovative, passionate about science, and can generate and lead original projects in a global R&D environment. The role will be primarily office-based, with some national and/or international travel to support projects, participate in team development meetings and attend conferences.What you will be doing on daily basis? You will be…Coordinating analyses within AstraZeneca's Centre for Genomics ResearchApplying innovative quantitative genomic analyses to large-scale cohort studies to identify clinically relevant disease and response lociDeliver novel insights into the biology of disease, validation of new targets for medicines and the improvement of selection of patients for clinical trialsProviding detailed reports regarding the study design, analysis approach and research findings and presenting to study teamsChampion and lead the strategic direction of own projects and initiatives.Seek and apply best practices in processes, data analysis, and decision-making in leading project teams in a virtual environmentContribute to the overall success of the wider AstraZeneca BioPharmaceuticals R&D functions.Ensuring own work, and work of team, is compliant with Good Laboratory Practice, Safety, Health and Environment standards and all other internal AstraZeneca standards and external regulationsQualifications, Skills and Experience Required:Essential:Degree in MedicinePhD degree (or equivalent experience)Experience in large-scale data analysisAbility to communicate effectively with team members and non-experts, both verbally and through documentationHigh level understanding or interest in the potential of genomics to impact drug discoveryIn-depth understanding of medicine in its broadest contextDesire and willingness to 'Follow the Science' beyond core disease area of expertiseAbility to carry out duties under minimal supervisionExcellent interpersonal skills and willingness to work within a team in a quickly evolving environmentTrack record of peer-reviewed publications in high-level scientific journalsDesirable:Previous experience in a similar roleExperience harmonising clinical phenotype information and diverse health datasetsPragmatic experience with data querying and data exploration toolsExperience in case-control sequencing based statistical analysesExperience quantifying and interpreting the clinical relevance of rare variantsFamiliarity working on genomics studies involving one of AstraZeneca's core therapeutic areas (see: https://www.astrazeneca.com/our-therapy-areas.html)Clinical experience, now seeking entry to the biotech/pharmaceutical industryWhy AstraZeneca?Make a more meaningful impact to patients' lives around the globeAt AstraZeneca we're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There's no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration. Always committed to lifelong learning, growth and development.Where can I find out more?Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/Follow AstraZeneca on Facebook https://www.facebook.com/astrazenecacareers/Follow AstraZeneca on Instagram https://www.instagram.com/astrazeneca_careers/?hl=en#J-18808-Ljbffr
