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Tipo de empleo: Jornada completa
Ubicación: 08028 Barcelona, Barcelona provincia
Descripción completa del empleo We are recruiting an Associate Director, Translational Medicine Assay Strategist, Immuno-Oncology, AstraZeneca Oncology R&D.
Location: Barcelona
Do you feel passionate about the possibilities of outstanding science changing lives of cancer patients? Do you have a background in oncology and/or translational research and an interest in working with Cell Therapies or immune bispecifics as part of an exciting portfolio? If so, this may be the role for you.
We currently have an exciting opportunity for a highly motivated Associate Director to join our translational medicine team supporting our exciting internal Cell Therapy programs.
About AstraZeneca AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialization of prescription medicines for some of the world's most serious diseases. But we're more than one of the world's leading pharmaceutical companies. Within AstraZeneca Oncology R&D, we are committed to advancing the science to deliver life-changing medicines to patients most in need.
What you'll do/Job description We are seeking an Associate Director in Oncology Translational Medicine to manage and deploy clinical trial assays, ensuring delivery of high quality translational data within our internal Cell Therapy oncology project portfolio teams.
Responsibilities Delivering translational assay readiness for pre-clinical therapies through Ph 2 clinical studies based on the best available science and technologies.
Generating assays and delivering data on disease linkage to guide indication selection and support patient selection hypotheses.
Support clinical implementation of assays for target engagement, pharmacodynamic, and mechanism of action biomarkers.
Key assays types are Flow Cytometry, IHC, transcriptomics, soluble proteins, and ctDNA.
Deliver data to reliably and quantifiably inform clinical decisions for selecting therapeutically relevant doses and schedules.
Surveying and communicating current landscape of translational assays in academic and industry settings.
Understanding key cancer pathway interactions, feedback mechanisms, and features of tumor microenvironment in clinical samples to guide rational drug combinations.
Defining novel mechanisms of resistance to targeted therapies by studying tumors at relapse and methods to assess them.
Influencing translational strategy across the AZ portfolio.
Collaborating across Translational Medicine and Clinical teams to facilitate appropriate incorporation of Translational Medicine strategies for molecules in early phases of development in Oncology.
Collaborating with clinical operations and clinical teams to define sample collection, lab manuals and clinical study protocols, and biomarker analyses in clinical studies related to oncology.
Contributing to and ensuring the quality of Translational Medicine clinical study reports, data reviews and interpretations, presentations, scientific publications and recommendations to development teams and management for GNG decisions.
Leading internal and external research collaborations in areas of clinical technologies and oncology translational research.
Essential for the role PhD and/or MD with experience in drug development.
A minimum of 5 years' of relevant experience.
Experience in clinical trials and clinical operations.
In-depth knowledge of immunology, oncology, and translational science.
Broad experience in human clinical trial immune assays such as flow cytometry, IHC, RNAseq, multiplex cytokines, and functional studies.
Ability to drive, manage, execute and deliver results for complex multi-functional projects.
Highly developed problem solving and risk management skills, and attention to detail.
Highly developed collaborative working skills.
Ability to act as an external ambassador and to influence external organizations to enhance the image and reputation of AstraZeneca.
Proven ability to motivate and develop others.
Desirable for the role Expertise in Cell Therapy; T cell engaging bispecifics, or other immuno-oncology.
Project management experience desired.
Why AstraZeneca? At AstraZeneca we're dedicated to being a Great Place to Work, where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There's no better place to make a difference to medicine, patients and society.
An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We're on an exciting journey to pioneer the future of healthcare.
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