Your missionThe Josep Carreras Leukemia Research Institute (IJC) is a comprehensive cancer research center dedicated to researching and promoting innovation in the epidemiological, preventive, clinical, translational, and basic aspects of leukemia and other hematological malignancies, with the objective of finding a cure for these diseases. It was created in 2010 and has since experienced exponential growth. The IJC is part of the network of Research Centers of Excellence of Catalonia (CERCA) and was accredited as a Severo Ochoa Center of Excellence by the Ministry of Science, Innovation and Universities in 2024. The IJC's main headquarters is located within the Can Ruti Biomedical Campus, alongside other leading biomedical institutions, providing direct access to cutting-edge scientific and technological facilities, as well as complementary community services. The IJC has six headquarters integrated into reference hospitals, facilitating close collaboration between basic and clinical researchers, fostering translational research that integrates basic science with clinical practice.
We are seeking a Predoctoral Researcher for our institute.
RESEARCH DESCRIPTIONAggressive B-cell lymphomas are clinically and pathologically diverse and reflect multiple pathways of transformation involving oncogenic signaling, lymphoma-stroma crosstalk, and intrinsic protein homeostasis. Alterations in these highly regulated processes play a key role in the progression of the malignant clone and correlate with a high failure rate in treatment protocols. In the last decade, new therapies applied to the treatment of B-cell lymphoma have significantly improved the overall survival of these patients, but at present, no drug can cure these diseases. Our team focuses on the characterization of new drug targets and on the bench-to-bedside translation of innovative therapeutic strategies, using cutting-edge experimental models of diffuse large B cell lymphoma (DLBCL), mantle cell lymphoma (MCL), and transformed follicular lymphoma (tFL).
This contract is financed by the Department of Research and Universities of the Generalitat de Catalunya, Agency for Management of University Research Grants (AGAUR), within the framework of the call "Grants to support the scientific activity of the Research Groups of Catalonia (SGR-Cat-2021)", Research group Personalized therapies and molecular bases of aggressive B-cell lymphomas (TRANSFORB), reference 2021 SGR 01535.
MAIN RESPONSIBILITIESParticipate in a research project centered on the design, synthesis, and biological validation of a proteolysis targeting chimera (PROTAC) library targeting a specific oncogenic pathway in malignant B cells.Setup a collection of in vitro (3D spheroids) and in vivo (cell line- and patient-derived mice and chicken embryo chorioallantoic membranes (CAM) xenografts) for efficacy and safety studies.Develop analytical tools (multiomics, cell-based assays, in vitro/vivo imaging).Undertake experimental design, data analysis, and interpretation.Your profileWHAT WE NEED Highly motivated scientist with a Master degree to work in the fields of tumor preclinical modelling, drug development, and multiomics data integration in hematological cancers.Experience in anticancer drug design, cell culture, cell-based assays, cellular and molecular biology.Previous experience in computational chemistry will be positively valued.Good communication skills in English and ability to work independently.Open-minded, flexible, collaborative, with strong work ethics and values.Enthusiasm, proactivity, and a team player.Why us?WHAT WE OFFER 1 Year Temporary ContractFull time contract.The opportunity to contribute to cutting-edge translational research projects in the stimulating environment of the Josep Carreras Leukaemia Research Institute.The stimulating environment of the Barcelona metropolitan area.Opportunity for professional growth in an advanced research environment.How to apply?DEADLINE FOR APPLICATIONSPlease submit your application by 23/12/2024.
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