.Your missionThe Josep Carreras Leukaemia Research Institute (IJC) is a comprehensive cancer research center dedicated to conducting research and driving innovation in the epidemiological, preventive, clinical, translational, and basic aspects of leukaemia and other hematologic malignancies, with the final aim of finding a cure for these diseases. It was created in 2010 and has experienced exponential growth since then.The IJC is part of the network of Excellence Research Centers of Catalonia (CERCA) and was accredited as a Severo Ochoa Center of Excellence by the Ministry of Science, Innovation, and Universities in 2024. Since 2018, the Institute has also been accredited by the Scientific Foundation of the Spanish Association Against Cancer (FCAECC). Additionally, IJC is one of the centers integrated into the Institut de Recerca Germans Trias i Pujol (IGTP), accredited as an Accredited Health Research Institute (IIS) by the Carlos III Health Institute (ISCIII).The IJC's main headquarters is located within the Can Ruti Biomedical Campus, alongside other leading biomedical institutions, providing direct access to cutting-edge scientific and technological facilities, as well as complementary community services. The IJC has six locations integrated into reference hospitals: Hospital Germans Trias i Pujol, Hospital Clínic, Hospital Sant Pau, Hospital Trueta, Hospital del Mar, and Hospital San Joan de Déu. This facilitates close collaboration between basic and clinical researchers, fostering translational research that integrates basic science with clinical practice.The Chromatin Biology Laboratory is led by a PhD student. This contract is part of the grant PID2023-152319OB-I00 funded by MCIU/AEI/10.13039/501100011033/FSE+.MAIN RESPONSIBILITIESStudy the role of PIK3CA mutations in the vasculature.Generate and maintain a mouse colony of PIK3CA-related vascular malformation models.Perform preclinical studies in PIK3CA-related vascular malformations experimental settings.Characterize the functional impact of PIK3CA mutations in cultured endothelial cells.Perform scRNAseq experiments and analysis.Your profileWHAT WE NEEDMSc in Biology, Biomedicine, or similar.A high level of motivation and interest.Excellent communication and organizational skills.Good level of oral and written English.Experience in cellular and molecular biology, stress response.Good academic records that allow the candidate to apply for competitive PhD calls.Previous experience in stress response and/or sirtuin biology, as well as proteomic and/or genomic analysis, would be highly valued.Why us?WHAT WE OFFERA FPI PhD position for 4 years funded by MCIN/AEI/10.13039/501100011033 and FSE+.The stimulating environment of the Barcelona metropolitan area.An exciting and innovative research project.Incorporation into a well-established, dynamic, and highly motivated team.Working in the outstanding multidisciplinary research environment of the Josep Carreras Leukaemia Research Institute