Vac_67_2024_Researcher Assistant_Enhancer Regulation By Histone Variants | Lk664

.Your missionWe, the team of Marcus Buschbeck at the headquarters of the Josep Carreras Leukaemia Research Institute (Badalona, Barcelona, Spain), are looking for a motivated researcher to work on a main research line of the lab.The Buschbeck lab performs both basic and applied research. In our basic research, we aim to understand the molecular mechanism by which histone variants link epigenetic regulation to metabolism and nuclear organization. In our translational research, we mine the chromatin regulatory space for combinatorial drug targets that can improve the therapy of blood cancers.The research assistant will complete a research project aiming at dissecting the contributions of different domains of macroH2A1.2 to genome regulation and structure using cell engineering, microscopic, biochemical, and epigenomic methods. The contract is linked to the project 'NucleoSense - Enhancer regulation and nuclear metabolite sensing by histone variants' (PID2021-126907NB-I00). The specific tasks are related to objective 1 and 2 that are: To study how macroH2A affects enhancers genome-wide and to dissect the dynamics of macroH2A-dependent genomic regulation.Your profileA high level of motivation and interest.High-level of collaborative and communicative skills.Relevant expertise in chromatin biology.Technical expertise in cell culture methods, generation of genetically modified cell lines, molecular biology, and biochemistry.Knowledge about chromatin regulation and histone variants is a major plus.4 or more years of relevant work experience.Good level of English speaking and writing skills (required).Spanish (helpful).Why us?Incorporation in a multinational and highly collaborative team.An innovative and interdisciplinary research project.Mixed basic and clinical research environment of the Josep Carreras Leukaemia Research Institute.The international network of the Buschbeck lab.The stimulating environment of the Barcelona metropolitan area.Permanent contract "Indefinido por actividades científico-técnicas".The contract is funded by the Spanish Ministry of Science and Innovation (State Investigation Agency), grant number PID2021-126907NB-I00, AEI/10.13039/501100011033.Co-funded by European Regional Development Fund.DeadlineTo apply for this opportunity, please submit your application at your earliest convenience. We will evaluate applications on a rolling basis until September 9th, 2024.About usThe mission of the Josep Carreras Institute is to conduct research and drive innovation in the epidemiological, preventive, clinical, translational, and basic aspects of cancer, with a special emphasis on leukaemia and other hematologic malignancies, with the final aim of finding a cure for these diseases