.- You are here:Home > Lab Manager in the Mechanics of Organelle Remodeling LaboratoryLab Manager in the Mechanics of Organelle Remodeling LaboratoryLab Manager in the Mechanics of Organelle Remodeling LaboratoryThe InstituteThe Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end and innovative technologies.The successful candidate will join the Mechanics of Organelle Remodeling Group. They will provide key support for smooth running of the laboratory via management tasks that include project support, cell culture, molecular biology experiments, reagent preparation, equipment and inventory maintenance/purchases, as well as training of PhD and Post-Docs. Their essential work will aid researchers in addressing an exciting question in mechanobiology: how mammalian cells mechanically regulate the dynamics of nuclear RNA-processing organelles to drive vital cellular processes in health and/or disease.About the labGroup leader: Adel Al Jord, Ph.DTo function, organisms rely on vital organs which, in turn, rely on cell division and specialization. At the subcellular scale, these universal cellular processes are notably driven by robust mechanisms of organelle remodeling. Our lab's broad interest lies in discovering these mechanisms, which are critical for the fundamental understanding of organisms in health and disease, as well as for enhanced organ engineering strategies.A prominent research focus is the relation between physical forces and the remodeling of essential nuclear RNA-processing organelles known as biomolecular condensates. We pioneered in revealing that, in germ cells, cytoskeletal forces mechanically remodel and regulate nuclear condensates across scales for reproductive success. Whether somatic cells, which compose the majority of cells in an organism, evolved this mechanical mechanism of organelle remodeling remains a mystery. However, our new evidence indicates that this mechanism is deployed by mammalian somatic cells within diverse physiological and pathological contexts. We therefore aim to venture into these unexplored grounds of nuclear condensate mechano-regulation across somatic cell types in health and disease. The research objective is to decipher how cytoskeletal forces impact nuclear dynamics across scales, from organelle remodeling down to RNA-processing regulation, and how this physical link influences somatic cell division and specialization.To attain this aim, our research follows a cross-disciplinary approach, bridging methods from systems, cell, molecular, and synthetic biology along with computational and biophysical tools
