.Vall d'Hebron Research Institute (VHIR) offers a position for a Predoctoral researcher within the Laboratory of the Cardiovascular Diseases Research Group to participate in the project Inhibition of mitochondrial sodium / calcium exchanger, NCLX, as a therapeutic strategy to reduce myocardial ischemia-reperfusion injury during myocardial infarction, recently funded by Instituto de Salud Carlos III, from Ministerio de Ciencia, Innovación y Universidades (PI23 / 00260).Education and qualifications: Required:Degree in Health Sciences (Biology, Biomedicine, Pharmacy, Veterinary Medicine, or a related discipline).Master's degree.High academic marks (degree and master's) are necessary.Good communication skills and fluency in spoken and written English.It is essential to send the academic record, including the mean qualification.Desired:Strong sense of responsibility, initiative, self-motivation, and social skills as key personal abilities.Ability to work independently.Previous publications.Research stages abroad.Accreditation for the use of animals in research.Experience and knowledge: Good knowledge of animal physiology, especially in the cardiovascular system, will be positively valued.Previous experience in molecular biology methods and research.Good molecular biology background and experience in molecular biology techniques (Western Blot, PCR, immunofluorescence, etc).Critical thinking including capacity to analyse and evaluate information critically and to develop innovative solutions to research problems.Main responsibilities and duties: To develop the doctoral thesis project and collaborate in other projects of the research group.To develop their own translational research project to solve an unmet clinical issue in cardiology.This includes designing, performing, and interpreting the results obtained in both in vivo and in vitro experiments, including the use of animal models, data measurement, and statistical analyses.To join the research team and collaborate and support other research members in the development of their projects.To generate a fruitful discussion within the group.Present and defend the results obtained in national and international scientific meetings.Participation in group meetings and other activities.Labour conditions: Position: Full-time predoctoral position (40h/week) after application to a research grant (including PFIS, AGAUR, etc).Starting: According to the conditions established by the grant holder.Duration: 4 years.Gross annual salary: According to the conditions established by the grant holder.Project Summary: Background: A key role for the mitochondrial sodium / calcium exchanger, NCLX, in reactive oxygen species (ROS) production during ischemia has been recently unveiled in endothelial and neuronal cells. Preliminary results show that NCLX inhibition can also abolish ROS production during reperfusion and reduces infarction in a mouse model of stroke