Do you feel passionate about the possibilities of great science changing the lives of cancer patients? Do you have a background within oncology and/or translational research and an interest in working with antibody drug conjugates (ADCs)? If so, this may be the role for you.We currently have an exciting opportunity for a highly motivated Associate Director/Director to join our team of translational medicine leads supporting our internal ADC programs.ABOUT ASTRAZENECAAstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development, and commercialisation of prescription medicines for some of the world's most serious diseases.Within AstraZeneca Oncology R&D, we are committed to advancing the science to deliver life-changing medicines to patients most in need. With a combination-focused pipeline that exploits the power of six scientific platforms (Immuno-Oncology, Tumor Drivers and Resistance, DNA Damage Response, Antibody-drug Conjugates, Cell Therapy, and Epigenetics), we are motivated by a dedication to scientific discovery and collaboration that will one day help eliminate cancer as a cause of death.The Translational Medicine function exists within AstraZeneca R&D to ensure effective and strategic biomarker studies for Oncology project teams. The Translational Medicine team is the single point of accountability for delivery of robust, scientifically-driven biomarkers to all project teams, providing feasibility assessments, technical validation, centralized biomarker analysis capability for clinical samples, and delivery of translational science research.We are looking for a highly motivated translational medicine leader to support biomarker activities in early as well as late-stage clinical development.What you'll do/Job descriptionWe are seeking an Associate Director/Director in Oncology Translational Medicine Strategist to develop biomarker strategies and ensure delivery within our internal ADC oncology project portfolio teams.Responsibilities:Delivering translational science and biomarker strategies for early and late development oncology assets through Ph1 to Ph 3 clinical studies based on the best available science and technologies.Generating disease linkage data to guide indication selection and targeted patient populations.Measuring target engagement and pharmacodynamic biomarkers reliably and quantifiably to advise clinical decisions for selecting therapeutically relevant doses and schedules.Understanding key cancer pathway interactions and features of the tumor microenvironment in clinical samples to guide rational drug combinations.Defining novel mechanisms of resistance targeted therapies by studying tumors at relapse.Influencing translational strategy across the AZ portfolio.Collaborating with Oncology Research, Translational Medicine, and product development teams to facilitate appropriate incorporation of Translational Medicine strategies for molecules in early to late development in Oncology.Collaborating with clinical operations and clinical teams to define sample collection, lab manuals, and clinical study protocols, and biomarker analyses in clinical studies related to oncology.Contributing to and ensuring the quality of Translational Medicine clinical study reports, data reviews and interpretations, presentations, scientific publications, and recommendations to development teams and management.Leading internal and external research collaborations in areas of clinical technologies and oncology translational research.Essential for the rolePhD and/or MD with experience in oncology drug development.A minimum of 5 years of relevant experience.In-depth knowledge of oncology disease area biology (solid tumors) and translational science.Ability to drive, manage, execute, and deliver results for complex multi-functional projects.Highly developed problem-solving and risk management skills, and attention to detail.Highly developed collaborative working skills.Ability to act as an external ambassador and influence external organisations to enhance the image and reputation of AstraZeneca.Proven ability to motivate and develop others.Desirable for the roleExpertise in antibody drug conjugates.Why AstraZeneca?At AstraZeneca we're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There's no better place to make a difference to medicine, patients, and society. An inclusive culture that champions diversity and collaboration, and is committed to lifelong learning, growth, and development.Date Posted: 18-jul-2024Closing Date: 07-ago-2024AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible. We believe that the more inclusive we are, the better our work will be.
#J-18808-Ljbffr
