Pfizer Senior Scientist in Bothell, United States ROLE SUMMARYAs a Senior Scientist, you will participate and play a critical role in pre-clinical drug discovery and development of ADC therapies spanning different payload classes. You will be responsible for designing and executing in vivo studies to evaluate the efficacy, safety and pharmacokinetics (PD)/pharmacodynamics (PD) relationship of ADC candidates. You will provide technical and scientific expertise in in vivo Pharmacology across Oncology R&D to enable target identification, validation, prioritization, and efficient drug discovery. You will collaborate closely with cross-functional teams to drive development of novel therapeutic agents from concept to clinic.ROLE RESPONSIBILITIESLead in vivo pharmacology studies, focused on evaluating and establishing efficacy, PK/PD relationship, combination strategy, biomarker identification and analysis.Design, develop and execute in vivo studies to evaluate and assess the therapeutic potential of ADC candidates in oncology models CDX/PDX/GEMM/Syngeneic models.Work within multi-functional teams to support target identification, validation, drug discovery and combination therapy.Effectively manage study timeline and coordinate study logistics with cross functional program teams.Develop and characterize new in vivo mouse models, including cell-line derived xenografts, syngeneic tumor and genetically engineered mouse (GEM) models, to study biologic mechanisms and support exploration of novel cancer immune therapeutics and targeted therapies.Proficiency in utilizing software such as GraphPad Prism, electronic lab notebooks, Microsoft Office etc. for data analysis and figure generation.Quality documentation and interpretation of experimental results.Presentation of results within a multidisciplinary team environment.Ensure appropriate use of animals in compliance with all regulatory requirements and internal standards.QUALIFICATIONSMust HavePh.D. in Cancer Biology, Immunology or related discipline.Experience with animal models of human cancers.Proficiency in cell culture, passaging and harvesting cells is required.Hands on in vivo skills (IV, PO, SC, IP dosing), blood/tissue collection.Excellent written and oral communication and presentation skills.Experience integrating biological concepts into experimental design.PreferredExperience with GEMM and humanized models.Experience with Antibody Drug Conjugates (ADC).Strong track record of publications or evidence of equivalent achievements in industry.PHYSICAL/MENTAL REQUIREMENTSLifting, sitting, standing, walking, bending, ability to perform mathematical calculations and ability to perform complex data analysis.Must be able to wear specialized protective clothing and PPE (e.G., lab coat, safety shoes, safety glasses).NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTSMust be willing and able to work after hours as needed to ensure study integrity.#J-18808-Ljbffr
