Johnson & Johnson Innovative Medicine is currently seeking a Senior Principal Scientist, In Silico Biologics Optimization to join our In Silico Proteins team within the Therapeutics Discovery organization, located in Spring House, PA.At Johnson & Johnson, we believe health is everything.Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal.Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity.Learn more at https://www.nj.om/.This is a technical position in the In Silico Proteins team within the Therapeutics Discovery organization, which provides computational support to accelerate and enhance discovery of the best drug candidates across all therapeutic modalities.This role will specifically interact with several functional groups across the Biologics Discovery organization to support the discovery and optimization of protein-based therapeutics.The successful candidate will work collaboratively between our functional groups and across organizations to develop rapid and scalable computational approaches for hit identification and optimization of lead protein therapeutics.Qualifications Ph..in Structural Biology, Bioinformatics, Computational Biology, Computer Science or other closely related field with at least 6 years of experience directly applied to problems in the Biotech/Pharmaceutical sector is required.Demonstrated ability to leverage commercial modeling software such as MOE (SVL scripting a plus) or BioLuminate (Schrodinger)and structural insight for mitigating protein liabilities to advance antibody-based protein therapeutics is required.Strong statistical understanding of advanced topics in machine learning and artificial intelligence applied to modeling protein structure and attributes is required.Proficiency in programming languages such as Python and R is required.Direct experience with HPC, cloud-based and GPU-accelerated compute platforms is preferred.Ability to work in multi-disciplinary teams, excellent interpersonal skills is required.Excellent organization and communication skills, with the ability to convey complex computational concepts effectively to a non-expert audience is required.The position is located in Spring House, PA and may require approximately 10% travel.Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer.All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.https://www.areers.nj.om/data-science IND7#J-18808-Ljbffr
