Postdoctoral Researcher in the group 'Evolutionary Processes Modeling'The InstituteThe Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries.
The CRG is composed of an interdisciplinary, motivated, and creative scientific team supported by a flexible and efficient administration and high-end innovative technologies.
We are looking for a postdoctoral researcher to join the 'Evolutionary Processes Modeling' group.About the groupWe use computational analysis of sequencing data together with population genetics predictions and statistical modeling to answer questions about mutational processes and selective pressures in cancer cells and in the human population.
The ideal candidate should be highly motivated and eager to work on evolutionary and biological problems through the use and development of computational and statistical approaches.
The candidate will analyze data, develop models for tumor DNA sequencing data, develop a computational pipeline, and test biological hypotheses.Cancer is a genetic disease, subject to population genetics forces like mutation, selection, and stochasticity.
Our group is particularly interested in how the evolution and survival of cancer cell populations relies on mutation influx and in how we can identify cancer driver events from observed mutation data.
To this end, we develop mathematical and computational approaches to estimate mutation rates, tumor growth dynamics, and selection.
Analysis of the mutational processes acting in cancer genomes allows us to learn about carcinogenic mutagens, while studying the spatial genetic heterogeneity of tumors tells us about the tumor mode of growth.
Estimates of the strength of selection in cancer allow a prioritization of genes and non-coding regions by their disease relevance, with the ultimate goal of promoting therapeutic advances.QualificationsYou are familiar with the principles of evolutionary processes or population genetics.You have experience with computer programming.You have experience with modeling, statistical analysis, and/or machine learning.Experience with DNA- or RNA-sequencing data analysis is a plus.Education and trainingYou hold a PhD degree in population genetics, physics, statistics, bioinformatics, or a related discipline.LanguagesYou are fluent in English.Technical skillsYou have experience with computational data analysis and are familiar with modeling and statistical analysis.CompetencesYou have highly developed organizational skills and good communication skills.The Offer – Working ConditionsContract duration: Technical and scientific activities contract estimated 1 year, to be extended up to a maximum of 3 years.#J-18808-Ljbffr