.The Vall d ´Hebron Institute of Oncology (VHIO) Seeks a "Postdoctoral Researcher"Reference: 2024-057-01Application deadline: Until filledNumber of vacancies: 1Job description:The Cancer Genome Engineering Group has an open position for a postdoctoral researcher to join the team. We are looking for a motivated scientist capable of leading their research project and wanting to work as a team member in a collegial and supportive environment.Our group is centered on understanding how copy number alterations (CNAs) contribute to disease progression and therapy resistance. We are particularly interested in the role of CNAs driving immune evasion, intra-tumor heterogeneity, and cancer genome evolution.To answer this major challenge, we use state-of-the-art genome engineering approaches combined with in vivo models of cancer to gain deep mechanistic insight into the biology of CNAs.The postdoctoral researcher will work on developing in vitro and in vivo mouse models of cancer, along with novel genome engineering methods to study clinically relevant CNAs. The project also entails the incorporation of CRISPR-Cas9 screens (in vitro and in vivo), as well as the in-depth analysis of anti-tumor immunity during disease progression and in response to immunotherapy.Responsibilities:Development of in vitro and in vivo models: Design and conduct experiments using cancer models, including mouse models, to study copy number alterations (CNAs).Application of genome engineering techniques: Utilize advanced genome-editing methods, such as CRISPR-Cas9, to investigate clinically relevant CNAs.Execution of CRISPR-Cas9 screens: Implement and analyze CRISPR-Cas9 screens, both in vitro and in vivo, to identify genes involved in cancer progression and therapy resistance.Study of anti-tumor immunity: Investigate the impact of CNAs on anti-tumor immune responses during cancer progression and in response to immunotherapy.Collaboration and teamwork: Work closely with team members in a collaborative and supportive environment, contributing to collective research goals.Data analysis and interpretation: Analyze experimental data and interpret findings to understand the mechanistic role of CNAs in cancer biology and therapy resistance.Presentation and publication of research: Present research findings at conferences and contribute to scientific publications.Requirements:What do we need?PhD degree in biomedical research or similar field (degree not needed at the time of application but will be required when the successful candidate joins the group).Prior experience with cancer genetics and mouse models will be viewed positively but are not strict requirements.Desirable skills:TeamworkCritical thinkingMultidisciplinaryTime managementPlanning capacityAdditional information:What we offer?The possibility of developing your professional career in a competitive environment
