Pfizer Principal Scientist, Molecular & Complex Cell Technologies in Bothell, United StatesWhy Patients Need You This position will provide the opportunity to make a positive impact during early stages of cancer drug development by optimizing the process of evaluating drug candidates and de-risking potential toxicities. These efforts will ultimately contribute to the larger goal of making therapeutics safer and more effective for cancer patients.
What You Will Achieve The successful candidate will work with multidisciplinary project teams to advise, develop and implement cutting-edge in vitro technologies such as complex cell culture, organoids, and microphysiological systems to support therapeutic platform development, target evaluation, candidate optimization and selection, and mechanistic investigations.
How You Will Achieve It The candidate will have the ability to work independently with the support of laboratory personnel. The position is highly collaborative across local and global functions within Research and Development and external partners.
Collaborate with multidisciplinary project teams to develop and implement in vitro Novel Alternative Methods (NAMS) for screening, candidate selection, and/or mechanistic studies to de-risk toxicity.Serve as a local subject matter expert and point person for collaborations with the Cellular & Molecular Investigative Toxicology Team in Groton CT.Liaise with Research team members and Toxicology program leads to develop, implement, and interpret in-vitro tissue-based assays to generate data that may inform go/no go decisions.Network within Drug Safety R&D (DSRD) and other group global experts to share learnings and enhance understanding of the strengths and limitations of NAMs.Manage and coordinate work involving NAMs with external partners.Supervise a small technical group to run, collect data, and perform analyses.Keep up to date with emerging literature and science in the NAMs, Microphysiologic Systems, and Toxicological Sciences.Stimulate interest in the respective area through publication, presentation, and networking internally and externally.Qualifications Must-Have Ph.D. degree in cell/molecular biology, toxicology, immunology, or related field with 3+ years post-doc experience. Expertise in tissue/cell culture and in vitro analytical methodologies.Strong organizational, interpersonal, teamwork, written and verbal communication skills.Ability to prioritize and manage multiple projects and activities while managing timelines.Nice-to-Have 3 year's experience in biotech/pharm.Experience working with microphysiological systems and familiarity with complex cell cultures.Passionate about developing and working with novel alternative methods.Knowledge of toxicological studies.NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS Occasional travel may be requested. Laboratory work requires adherence to safe work practices and procedures such as use of Personal Protective Equipment (gowning, gloves, protective eyewear, etc.).
Other Job Details: Location: Bothell, WA (Seattle Area)
Eligible for Relocation Package - YES PHYSICAL/MENTAL REQUIREMENTS Position requires activities such as walking, standing, sitting on a stool, and light lifting as would be incurred in a laboratory environment. Laboratory work requires adherence to safe work practices and procedures such as use of Personal Protective Equipment (gowning, gloves, protective eyewear, etc.).
NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS Occasional travel may be required.
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