Predoctoral Position In Translational Immunology And Immunotherapy

Organisation/Company: FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADADepartment: AdministrationResearch Field: Biological sciences » BiologyResearcher Profile: First Stage Researcher (R1)Positions: PhD PositionsCountry: SpainApplication Deadline: 27 Nov 2024 - 23:59 (Europe/Madrid)Type of Contract: TemporaryJob Status: Full-timeIs the job funded through the EU Research Framework Programme? Not funded by a EU programmeIs the Job related to staff position within a Research Infrastructure? NoOffer Description Synergistic combinations for cancer Immunotherapy based on agonist immunotherapy agents and interference with pro-tumoral Inflammation. SynerCombIT.Transformative opportunities in the field of cancer immunotherapeutics usually stem from combinations involving agents of immunotherapy among themselves or in synergistic combinations with either chemotherapy or antiangiogenics.However, multiple lines of evidence show that there exist inflammatory responses in cancer-bearing hosts that act to curtail the efficacy of immunotherapy.Such deleterious activities are orchestrated by soluble mediators and are mainly mediated by myeloid leukocytes (tumor-associated macrophages and neutrophils).The overarching goal of SynerCombIT is to use innovative preclinical and clinical research to test therapeutic approaches against difficult to treat mouse cancer models.The project will rely on genetically modified mouse strains, multiplex tissue immunofluorescence, transcriptomics, and a variety of in-vivo and ex-vivo functional immune assessments.The selected candidate will work in a dynamic and collaborative environment, participating in an innovative project that addresses fundamental questions in the field of immunotherapy.#J-18808-Ljbffr