Predoctoral Position In Translational Immunology And Immunotherapy

Organisation/Company: FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLICADA
Department: Administration
Research Field: Biological sciences » Biology
Researcher Profile: First Stage Researcher (R1)
Positions: PhD Positions
Country: Spain
Application Deadline: 27 Nov 2024 - 23:59 (Europe/Madrid)
Type of Contract: Temporary
Job Status: Full-time
Is the job funded through the EU Research Framework Programme? Not funded by a EU programme
Is the Job related to staff position within a Research Infrastructure? No
Offer Description Synergistic combinations for cancer Immunotherapy based on agonist immunotherapy agents and interference with pro-tumoral Inflammation. SynerCombIT.
Transformative opportunities in the field of cancer immunotherapeutics usually stem from combinations involving agents of immunotherapy among themselves or in synergistic combinations with either chemotherapy or antiangiogenics.
However, multiple lines of evidence show that there exist inflammatory responses in cancer-bearing hosts that act to curtail the efficacy of immunotherapy.
Such deleterious activities are orchestrated by soluble mediators and are mainly mediated by myeloid leukocytes (tumor-associated macrophages and neutrophils).
The overarching goal of SynerCombIT is to use innovative preclinical and clinical research to test therapeutic approaches against difficult to treat mouse cancer models.
The project will rely on genetically modified mouse strains, multiplex tissue immunofluorescence, transcriptomics, and a variety of in-vivo and ex-vivo functional immune assessments.
The selected candidate will work in a dynamic and collaborative environment, participating in an innovative project that addresses fundamental questions in the field of immunotherapy.

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