The Institute The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed of an interdisciplinary, motivated, and creative scientific team supported by a flexible and efficient administration and high-end innovative technologies.
In April 2021, the Centre for Genomic Regulation (CRG) received the renewal of the 'HR Excellence in Research' Award from the European Commission. This recognition reflects the Institute's commitment to developing an HR Strategy for Researchers, designed to align practices and procedures with the principles of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers (Charter and Code).
Please check out our Recruitment Policy.
The Role We are seeking a motivated postdoctoral scientist interested in dissecting genome regulatory mechanisms underlying human diabetes. The successful applicant will develop cell-based model systems such as human stem cell-derived beta cells, using single-cell genomic read-outs, and will explore poorly understood genome regulatory mechanisms. The work will be performed within a multidisciplinary lab located in the CRG.
About the Lab The Regulatory Genomics and Diabetes lab aims to uncover genetic mechanisms causing diabetes mellitus and to develop therapeutic avenues. The group is particularly interested in understanding how genomic information directs cell-specific gene expression and pinpointing gene regulatory defects underlying human disease.
The team brings together diverse expertise, ranging from work with mutant stem cell-derived beta cell organoids, engineered mouse models, single-cell epigenomics, large-scale genetic screens, statistical genetics, and the integration of genetic and regulatory data. This multidisciplinary approach provides unique opportunities to engage in collaborative projects that combine experimental and computational methods. The lab encourages wet lab scientists to engage in their own data analysis and provides a supportive environment to this end. The group is funded by the European Research Council, the Spanish Ministry of Science and Innovation, Generalitat de Catalunya, an AXA chair, European Foundation for the Study of Diabetes, the Marie Sklodowska-Curie Actions program, and a CIBERDEM diabetes network. The lab forms part of international consortia focused on advancing research in regulatory genomics, single-cell genomics, and human genetics.
Recent studies from the lab include:
A lineage-specific gene transcription and splicing hierarchy that is disrupted in type 2 diabetes (In review).Large-scale discovery of molecular targets for precision treatment of HNF1A-deficient diabetes (In review).Transcription regulation by long non-coding RNAs and their disease relevance (Nat Rev Mol Cell Biol, 2024).HASTER lncRNA promoter is a cis-acting transcriptional stabilizer of HNF1A (Nat Cell Biol 2022).Pancreas agenesis mutations disrupt a lead enhancer controlling a developmental enhancer cluster (Dev Cell, 2022).Human pancreatic islet 3D chromatin architecture provides insights into the genetics of type 2 diabetes (Nat Genet 2019).Whom Would We Like to Hire? Professional Experience Must Have Solid track record in molecular and cell biology and expertise in one of the following fields: genome/epigenome editing technologies, single-cell genomic methods, or in the development of protocols with this technology.Expertise in next-generation sequence analysis.Publication track record in these areas with a leading authorship role.Education and Training A PhD in a relevant field.Languages You are proficient in English.Technical Skills You have advanced MS Office skills.Competences Highly developed organizational and communication skills.Ability to work in a team.The Offer – Working Conditions Contract Duration: Contract for Technical and Scientific Activities – estimated duration of 2 years, with the possibility of renewal.Estimated Annual Gross Salary: Salary is commensurate with qualifications and consistent with our pay scales.Target Start Date: January 2025.We provide a highly stimulating environment with state-of-the-art infrastructures and unique professional career development opportunities. To check out our training and development portfolio, please visit our website in the training section.
We offer and promote a diverse and inclusive environment and welcome applicants regardless of age, disability, gender, nationality, ethnicity, religion, sexual orientation, or gender identity.
The CRG is committed to reconciling work and family life of its employees and offers an extended vacation period and the possibility to benefit from flexible working hours.
#J-18808-Ljbffr