.Organisation/Company Centre for Genomic RegulationResearch Field Biological sciences » OtherResearcher Profile First Stage Researcher (R1) Recognised Researcher (R2)Positions Postdoc PositionsCountry SpainApplication Deadline 8 Jan 2025 - 23:59 (Europe/Madrid)Type of Contract OtherJob Status Full-timeHours Per Week 40Offer Starting Date 15 Jan 2025Is the job funded through the EU Research Framework Programme?
Not funded by a EU programmeIs the Job related to staff position within a Research Infrastructure?
NoOffer Description The InstituteThe Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries.
The CRG is composed of an interdisciplinary, motivated and creative scientific team supported by a flexible and efficient administration and high-end innovative technologies.We are seeking a motivated postdoctoral scientist to lead a project in one of these two areas:Analysis and discovery of rare noncoding mutations causing diabetes, using advanced statistical genetics, computational regulatory genomics, and analysis of whole genome sequences in unique patient cohorts.Using computational strategies to develop a high resolution epigenomic technology with translational potential.About the labThe Regulatory Genomics and Diabetes lab aims to uncover genetic mechanisms causing diabetes mellitus and to develop therapeutic avenues.
The group is particularly interested in understanding how genomic information directs cell-specific gene expression and pinpointing gene regulatory defects underlying human disease.The team brings together diverse expertise, ranging from work with mutant stem cell-derived beta cell organoids, engineered mouse models, single cell epigenomics, large-scale genetic screens, statistical genetics, and the integration of genetic and regulatory data.
This multidisciplinary approach enables collaborative projects that combine experimental and computational methods.Recent studies from the lab include:A lineage-specific gene transcription and splicing hierarchy disrupted in type 2 diabetes.
(In review).Large-scale discovery of molecular targets for precision treatment of HNF1A-deficient diabetes.
(In review).Transcription regulation by long non-coding RNAs and its disease relevance (Nat Rev Mol Cell Biol, 2024).HASTER lncRNA promoter as a cis-acting transcriptional stabilizer of HNF1A (Nat Cell Biol 2022).Pancreas agenesis mutations disrupting a lead enhancer controlling a developmental enhancer cluster.
(Dev Cell, 2022).Human pancreatic islet 3D chromatin architecture providing insights into the genetics of type 2 diabetes (Nat Genet 2019).Whom would we like to hire?Professional experienceMust HaveYou hold a PhD (or equivalent experience) in statistical genetics, genome or epigenome data analysis, or related fields