.Postdoctoral Scientist, Computational Epigenomics and Genetics Statistical genetics, gene regulation, diabetes Description The Institute The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries.
The CRG is composed of an interdisciplinary, motivated, and creative scientific team supported by a flexible and efficient administration and high-end technologies.
We are seeking a motivated postdoctoral scientist to lead a project in one of these two areas: Analysis and discovery of rare noncoding mutations causing diabetes, using advanced statistical genetics, computational regulatory genomics, and analysis of whole genome sequences in unique patient cohorts.
Using computational strategies to develop a high-resolution epigenomic technology with translational potential.
About the Lab The Regulatory Genomics and Diabetes lab aims to uncover genetic mechanisms causing diabetes mellitus and to develop therapeutic avenues.
The group is particularly interested in understanding how genomic information is used to direct cell-specific gene expression and to pinpoint gene regulatory defects underlying human disease.
The team brings together diverse expertise, ranging from work with mutant stem cell-derived beta cell organoids, engineered mouse models, single cell epigenomics, large-scale genetic screens, statistical genetics, and the integration of genetic and regulatory data.
This multidisciplinary approach enables generating new datasets and experimental testing of in silico predictions.
The group is funded by the European Research Council, the Spanish Ministry of Science and Innovation, Generalitat de Catalunya, an AXA chair, European Foundation for the Study of Diabetes, the Marie Sklodowska-Curie Actions program, a CIBERDEM diabetes network, and a collaborative project with biotech.
The lab forms part of international consortia focused on advancing research in regulatory genomics, single cell genomics, and human genetics.
Recent Studies from the Lab Include: A lineage-specific gene transcription and splicing hierarchy that is disrupted in type 2 diabetes.
(In review).
Large-scale discovery of molecular targets for precision treatment of HNF1A-deficient diabetes.
(In review).
Transcription regulation by long non-coding RNAs and its disease relevance (Nat Rev Mol Cell Biol, 2024).
HASTER lncRNA promoter is a cis-acting transcriptional stabilizer of HNF1A (Nat Cell Biol 2022).
Pancreas agenesis mutations disrupt a lead enhancer controlling a developmental enhancer cluster.
(Dev Cell, 2022).
Human pancreatic islet 3D chromatin architecture provides insights into the genetics of type 2 diabetes (Nat Genet 2019).
Whom Would We Like to Hire?
Professional Experience Must Have: You hold a PhD (or equivalent experience) in statistical genetics, genome or epigenome data analysis, or related fields