The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries.
The CRG is composed of an interdisciplinary, motivated, and creative scientific team supported by a flexible and efficient administration and high-end innovative technologies.
In April 2021, the Centre for Genomic Regulation (CRG) received the renewal of the 'HR Excellence in Research' Award from the European Commission.
This is a recognition of the Institute's commitment to developing an HR Strategy for Researchers, designed to bring the practices and procedures in line with the principles of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers (Charter and Code).
We are seeking a postdoctoral researcher to work with a team on the mechanism by which cells secrete the right amount and quality of bulky cargoes like collagens, mucins, and chylomicrons.
Based on our data, we have suggested the involvement of transient tunnels that propel these bulk molecules from the endoplasmic reticulum lumen to the next compartment of the secretory pathway, thus bypassing the use of a vesicular intermediate.
TANGO1 and its binding partners mediate this event.
A number of new genes potentially involved in this biochemical reaction have been identified.
This role will require a mix of in vitro and in vivo analyses.
Optogenetically controlled function of TANGO1 and inhibitors are being used to address the mechanism both in healthy and fibrotic tissues.
About the lab: The lab has a group dedicated to addressing the mechanism by which bulky cargoes are exported from metazoan cells (Raote and Malhotra.
Ann.
Rev.
Biochem.
2021).
Structural and functional analyses of the key components such as TANGO1, identified in our lab, are the focus of the studies.
There are new gene products that likely function in the same pathway, but the mechanism of their action remains unaddressed.
We aim to visualize and characterize the route taken by the bulky cargoes for their export from the ER.
We are addressing the issue of how good collagens are selected while the misfolded collagens and mucins are degraded, and work is in progress to express the entire collagen production and secretion system in yeast.
By addressing these issues, we ultimately aim to understand how cells control the secretion of these molecules in the right quantity and of the right quality.
This is essential for the organization of cells in a tissue and a means to address collagen and mucin hypersecretion linked to human pathologies of tissue fibrosis.
Whom would we like to hire?
Professional experience:
Must Have:
Must have a comprehensive understanding and proven ability to modern approaches of molecular cell biology, imaging, genetic manipulation.
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