.Descripción: The Barcelona Institute for Global Health (ISGlobal) is a cutting-edge institute addressing global public health challenges through research, translation into policy and education. ISGlobal has a broad portfolio in communicable and non-communicable diseases including environmental and climate determinants, and applies a multidisciplinary scientific approach ranging from the molecular to the population level. Research is organized in five programs: Climate, Air Pollution, Nature and Urban Health; Environment and Health over the Lifecourse; Global Viral and Bacterial Infections; Malaria and Neglected Parasitic Diseases and Maternal Child and Reproductive Health. ISGlobal is accredited with the Severo Ochoa distinction, a seal of excellence of the Spanish Science Ministry.Lugar: Barcelona, Campus Clinic-CEKWHAT WE ARE LOOKING FOR: ISGlobal is seeking to hire a talented and highly motivated postdoctoral scientist interested in working in a research project investigating heterochromatin biology in malaria parasites. The contract is funded by the Spanish Ministry of Science, Innovation and Universities within the project PID2022-137863OB-I00 "Mecanismos de las respuestas transcripcionales a cambios en las condiciones del ambiente en el parásito de la malaria Plasmodium falciparum" financiado por MCIN/AEI/10.13039/501100011033/ FEDER.THE TEAM: The ISGlobal Malaria Epigenetics lab directed by ICREA Research Professor Alfred Cortés investigates the regulation of gene expression in the malaria parasite Plasmodium falciparum. We use a combination of approaches that include genome editing with CRISPR-Cas9 technology, state-of-the-art phenotypic characterisation and multi-omic approaches. Our ultimate goal is to generate high-quality basic knowledge that is relevant for the fight against malaria.ABOUT THE PROJECT: Plasmodium falciparum is responsible for the most severe forms of human malaria. Transcriptional regulation plays a key role in malaria parasite biology, as it controls fundamental processes such as life cycle progression, antigenic variation and adaptation to the conditions of the environment. Some of these processes are regulated at the epigenetic level, with a key role for euchromatin-heterochromatin transitions. In this project, we will investigate several aspects of heterochromatin dynamics and biological functions.TRAINING AND EXPERIENCE / QUALIFICATIONS:- A PhD in a discipline related to molecular and cellular biologySPECIFIC REQUIREMENTS:- Expertise in malaria research (P. falciparum cultures and manipulation, including genetic manipulation using CRISPR-Cas9)- Expertise in the analysis of transcriptional regulation and epigenetic processes (RT-qPCR, RNA-seq, ChIP-seq, etc), and, more specifically, expertise in heterochromatin biologyKEY RESPONSABILITIES:- The main tasks will be to design and perform experiments to study heterochromatin biology in P