.The Institute The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries.
The CRG is composed of an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end and innovative technologies.
In April 2021, the Centre for Genomic Regulation (CRG) received the renewal of the 'HR Excellence in Research' Award from the European Commission.
This is a recognition of the Institute's commitment to developing an HR Strategy for Researchers, designed to bring the practices and procedures in line with the principles of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers (Charter and Code).
Please, check out our Recruitment Policy.The role We are seeking a highly motivated Postdoctoral Researcher, ideally with a mixed/hybrid background in Molecular Biology (wet lab) & Bioinformatics (dry lab), to join the Epitranscriptomics and RNA Dynamics group (PI: Eva Novoa), to study the role of RNA modifications (the "epitranscriptome") in sperm RNAs using nanopore sequencing technologies.
Your work would be part of the project "Dissecting the role of sperm transcriptome dynamics in intergenerational inheritance through native RNA nanopore sequencing", which has been funded by the European Research Council (ERC).
In this project, we aim to study how different dietary intakes (e.G.
high fat diet) affect the sperm RNA populations and their RNA modifications, and how these changes in sperm RNA can lead to altered metabolic profiles in the next generations.About the lab Our lab is focused on deciphering the role that RNA modifications play in a large variety of cellular contexts, including the development of novel technologies to map RNA modifications.
In our lab, we are employing a combination of experimental (RNASeq, RIP-Seq polysome profiling, mouse/cell knockouts, Oxford Nanopore direct RNA sequencing) and computational techniques (NGS data analysis, algorithm development, machine learning) to unveil the secrets of three post-transcriptional regulatory layers: the epitranscriptome, RNA structure, and ribosome specialization.Whom would we like to hire?
Professional experience You will also possess the following key skills and attributes:Must Have You have a background in RNA biology.
You have basic programming/data analysis skills, preferably in Python or R. You have published at least one primary research paper during your PhD.
Desirable but not required/ Nice to have Wet lab You have experience in sperm RNA extraction techniques and/or sperm manipulation.
You have experience with Oxford Nanopore sequencing library preparation.
You have experience with microinjections in zygotes.
You have experience with rodents.
You have experience with Glucose Tolerance Tests (GTT) and/or Insulin Tolerance Tests (ITT) in mice