The Breast Cancer Group at CNIO has been awarded a 3-year grant for studying the dynamic changes in the functional status of the tumor immune infiltrate in response to immunotherapy and ADCs in real time. This project will combine work with cancer immunology models, patient samples (live patient-derived organoids) and high throughput techniques such as digital spatial profiling, highly multiparametric cytometry, single-cell RNAseq, and others, and will be executed in the translational research interphase in the context of an unit with clinical and basic science research. This is a fully funded position. We expect the candidate to be proficient at problem-solving and generate innovative approaches to make sense of the multi-modal data that will be obtained to understand the inter-patient differences in response to these drugs, and also, conduct mechanistic studies to unravel the causes of such differences. The candidate will interact and coordinate with the clinical teams for samples collection (serial blood sampling, tumor organoid establishment, etc), and have a relatively independent use of the mentioned technologies. Criterios de evaluación PhD in cancer research, immunology, or cancer immunology. At least 5 years of lab research experience (wet lab). 1-2 years of basic biocomputation experience. Technical skills: Highly multiparametric Flow Cytometry or Mass Citometry. Organoid culture. Animal research. Omic techniques such as digital spatial profiling, RNAseq, single-cell RNAseq. General wet-lab skills. English. Se ofrece The opportunity to be part of one of the few European Cancer Research Centres of excellence. An excellent working, multidisciplinary environment. Competitive salary. Contract linked to a project. Solicitudes Los/as interesados/as deberán remitir su C.V. indicando la Referencia: AIPOSICCM18 en el asunto del mail a la dirección de correo electrónico, de lo contrario la candidatura no podrá ser tenida en cuenta. #J-18808-Ljbffr