Barcelona Institute Of Science And Technology (BIST)Date: 03 OctLocation: BarcelonaThe Institute: The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed of an interdisciplinary, motivated, and creative scientific team supported by a flexible and efficient administration and high-end, innovative technologies. In April 2021, the CRG received the renewal of the 'HR Excellence in Research' Award from the European Commission, recognizing the Institute's commitment to developing an HR Strategy for Researchers, designed to align practices and procedures with the principles of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers.Please check out our Recruitment Policy: CRG Recruitment PolicyThe Role: We are seeking a postdoctoral researcher to develop a project focused on understanding whether the nuclear localization of metabolic enzymes can be used to predict cancer stage, grade, and response to therapy. The selected candidate will analyze mass spectrometry (MS) data to determine the enrichment of metabolic enzymes in the chromatin compartment. Such data will be validated with immunohistochemistry and immunofluorescence (with the help of a technician), and the selected candidate will develop a pipeline for image analysis and integration of different markers along with the subcellular localization of selected metabolic enzymes. The goal of this project is to develop novel guidelines for patient stratification based on the subcellular localization of enzymes.About the Lab: Our laboratory specializes in high-throughput image analysis, subcellular proteomics, transcriptomics, genetic screening, bioinformatics, and cell and molecular biology techniques. We are a group of about 10 people from different cultures and countries. We are part of the genome biology department at the CRG, and we aim to understand why metabolic enzymes localize to the nuclear environment and participate in specific chromatin functions.
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