.Ubicación:Barcelona, Barcelona provinciaDescripción completa del empleo:The Institute:The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed of an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end and innovative technologies.In April 2021, the Centre for Genomic Regulation (CRG) received the renewal of the 'HR Excellence in Research' Award from the European Commission. This is a recognition of the Institute's commitment to developing an HR Strategy for Researchers, designed to bring the practices and procedures in line with the principles of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers (Charter and Code).The role:We are seeking a postdoctoral researcher to develop a project focused on understanding whether the nuclear localization of metabolic enzymes can be used to predict cancer stage, grade, and response to therapy. The selected candidate will analyse mass spectrometry (MS) data to determine the enrichment of metabolic enzymes in the chromatin compartment. Such data will be validated with immunohistochemistry and immunofluorescence (with the help of a technician) and the selected candidate will develop a pipeline for image analysis and integration of different markers together with subcellular localization of selected metabolic enzymes. The goal of this project is to develop novel guidelines for patient stratification based on the subcellular localization of enzymes.About the lab:Our laboratory specializes in high-throughput image analysis, subcellular proteomics, transcriptomics, genetic screening, bioinformatics and cell and molecular biology techniques. We are a group of about 10 people from different cultures and countries. We are part of the genome biology department at the CRG, and we aim to understand why metabolic enzymes localize to the nuclear environment and participate in specific chromatin functions.Whom would we like to hire?Professional experience:Must Have:You have proven experience in bioinformatics.You have experience in image analysis, omics analysis, MS analysis.You have a first author publication.You are eligible for international or national fellowship programs, such as:EMBO postdoctoral fellowship (deadline 14th of February 2025)Marie Curie Postdoctoral fellowship (deadline 11th of September 2024)Juan de La Cierva postdoctoral fellowship (expected deadline January 2025)AECC postdoctoral fellowship (expected deadline November 2024)Desirable but not required:You have knowledge of cancer biology, in particular breast cancer.Education and training:You have a PhD in biological sciences, Molecular Biology, Computational Biology, Bioinformatics, or related fields.Languages:You are proficient in English (oral and written)
