The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed of an interdisciplinary, motivated, and creative scientific team supported by a flexible and efficient administration and high-end and innovative technologies.
Alternative splicing (AS) is the important process that allows the production of different messenger RNAs and proteins from a single gene in humans and other complex organisms. AS plays a crucial role in mechanisms controlling gene expression. Mutations affecting AS contribute to the development of many diseases, including cancer.
While drugs that target AS have recently entered the clinic and provided the first therapy for common genetic disorders, there is still much to be learnt about the mechanisms controlling splicing and their modulation by small molecules. Small molecule inhibitors of spliceosome assembly have been used to generate alterations in RNA processing in cancer cells leading to the synthesis of neoantigens. The role of the postdoc to be hired will be to contribute to the characterization of molecular mechanisms of AS regulation by small molecule modulators of RNA splicing, the generation of neoantigens, and their characterization for their potential use in immunotherapy. This is a collaborative project (CANCERNA) supported by the EC-funded H2020 Health Program.
About the team: The group of Juan Valcárcel at the Center for Genomic Regulation (CRG) of Barcelona has a long trajectory studying pre-mRNA splicing regulation. The group combines high-throughput methods with detailed biochemical and cellular assays and collaborates closely with other groups working on computational and structural biology to study molecular mechanisms and networks of alternative splicing regulation in cancer. The group also develops mechanism-based novel therapeutic approaches for oncology.
Whom would we like to hire?Professional experienceMust Have:You have a PhD in Molecular Biology.You have proven experience in Molecular Biology and Gene Regulation.Desirable but not required/Nice to have:Computational Biology Skills.Experience with RNA analysis.Experience with RNA and Disease.Education and trainingYou hold a PhD in Molecular Biology.LanguagesYou are proficient in English.Technical skillsHighly developed organizational skills.Capacity for teamwork.CompetencesHighly developed organizational skills.Capacity for teamwork.The Offer – Working ConditionsContract duration: Technical and scientific activities contract linked to the project (estimated until 31/05/2025 with the possibility to extend to 16 months).Estimated annual gross salary: Salary is commensurate with qualifications and consistent with our pay scales.We provide a highly stimulating environment with state-of-the-art infrastructures and unique professional career development opportunities.
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