The InstituteThe Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed of an interdisciplinary, motivated, and creative scientific team which is supported by a flexible and efficient administration and by high-end and innovative technologies.In April 2021, the Centre for Genomic Regulation (CRG) received the renewal of the 'HR Excellence in Research' Award from the European Commission. This is a recognition of the Institute's commitment to developing an HR Strategy for Researchers, designed to bring the practices and procedures in line with the principles of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers (Charter and Code).The roleAlternative splicing (AS) is the important process that allows the production of different messenger RNAs and proteins from a single gene in humans and other complex organisms. AS plays a crucial role in mechanisms controlling gene expression. Mutations affecting AS contribute to the development of many diseases, including cancer. While drugs that target AS have recently entered the clinic and provided the first therapy for common genetic disorders, there is still much to be learnt about the mechanisms controlling splicing and their modulation by small molecules. Small molecule inhibitors of spliceosome assembly have been used to generate alterations in RNA processing in cancer cells leading to the synthesis of neoantigens. The role of the postdoc to be hired will be to contribute to the characterization of molecular mechanisms of AS regulation by small molecule modulators of RNA splicing, the generation of neoantigens, and their characterization for their potential use in immunotherapy. This is a collaborative project (CANCERNA) supported by the EC-funded H2020 Health Program.About the teamThe group of Juan Valcárcel at the Center for Genomic Regulation (CRG) of Barcelona has a long trajectory studying pre-mRNA splicing regulation. The group combines high-throughput methods with detailed biochemical and cellular assays and collaborates closely with other groups working on computational and structural biology to study molecular mechanisms and networks of alternative splicing regulation in cancer. The group also develops mechanism-based novel therapeutic approaches for oncology. Juan Valcárcel obtained his PhD from work on influenza virus splicing regulation carried out in the lab of Juan Ortín at the Center of Molecular Biology Severo Ochoa in Madrid. After a postdoc with Michael Green at the University of Massachusetts, working on mechanisms of splice site recognition and regulation, he established his group at the European Molecular Biology Laboratory (EMBL) in Heidelberg in 1996. In 2002 the group moved to the newly created Center for Genomic Regulation (CRG) of Barcelona. He is a Research Professor of the Catalonian Institute for Research and Advanced Studies (ICREA) and associated Professor of the University Pompeu Fabra. Elected EMBO member in 2004, he was Deputy Coordinator of the European Alternative Splicing Network of Excellence and Coordinator of the RNAREG Consolider consortium, the European Innovation Council-funded TAONas-LUAD and the European Research Council-funded UNLEASH projects. He is a member of the Editorial Board of the Journals Molecular Cell, RNA, and Molecular and Cellular Biology as well as of the Scientific Advisory Boards of several Research Institutes and companies in Europe and the USA. He served as President of the RNA Society in 2017-2018 and as Past-President in 2019-2020. Our team is currently composed of 2 technicians, 1 lab manager, 2 PhD students, 5 postdocs, and 1 Staff Scientist.Whom would we like to hire?Professional experienceMust HaveYou have a PhD in Molecular Biology.You have proven experience in Molecular Biology and Gene Regulation.Desirable but not required/ Nice to haveComputational Biology Skills.Experience with RNA analysis.Experience with RNA and Disease.Education and trainingYou hold a PhD in Molecular Biology.LanguagesYou are proficient in English.Technical skillsHighly developed organizational skills.Independence.Professional ambition.Capacity for teamwork.CompetencesHighly developed organizational skills.Independence.Professional ambition.Capacity for teamwork.The Offer – Working ConditionsContract duration: technical and scientific activities contract linked to the project (estimated until 31/05/2025 with the possibility to extend to 16 months).Estimated annual gross salary: Salary is commensurate with qualifications and consistent with our pay scales.Target start date: September 2024.We provide a highly stimulating environment with state-of-the-art infrastructures, and unique professional career development opportunities. To check out our training and development portfolio, please visit our website in the training section.We offer and promote a diverse and inclusive environment and welcome applicants regardless of age, disability, gender, nationality, ethnicity, religion, sexual orientation, or gender identity.The CRG is committed to reconciling work and family life of its employees and is offering an extended vacation period and the possibility to benefit from flexible working hours.
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