The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed of an interdisciplinary, motivated, and creative scientific team supported by a flexible and efficient administration and high-end and innovative technologies.
Alternative splicing (AS) is the important process that allows the production of different messenger RNAs and proteins from a single gene in humans and other complex organisms. AS plays a crucial role in mechanisms controlling gene expression. Mutations affecting AS contribute to the development of many diseases, including cancer. While drugs that target AS have recently entered the clinic and provided the first therapy for common genetic disorders, there is still much to be learnt about the mechanisms controlling splicing and their modulation by small molecules. Small molecule inhibitors of spliceosome assembly have been used to generate alterations in RNA processing in cancer cells leading to the synthesis of neoantigens. The role of the postdoc to be hired will be to contribute to the characterization of molecular mechanisms of AS regulation by small molecule modulators of RNA splicing, the generation of neoantigens, and their characterization for their potential use in immunotherapy. This is a collaborative project (CANCERNA) supported by the EC-funded H2020 Health Program.
About the team The group of Juan Valcárcel at the Center for Genomic Regulation (CRG) of Barcelona has a long trajectory studying pre-mRNA splicing regulation. The group combines high-throughput methods with detailed biochemical and cellular assays and collaborates closely with other groups working on computational and structural biology to study molecular mechanisms and networks of alternative splicing regulation in cancer. The group also develops mechanism-based novel therapeutic approaches for oncology.
Whom would we like to hire? Professional experience Must Have You have a PhD in Molecular Biology.You have proven experience in Molecular Biology and Gene Regulation.Desirable but not required/Nice to have Computational Biology Skills.Experience with RNA analysis.Experience with RNA and Disease.Education and training You hold a PhD in Molecular Biology.
Languages You are proficient in English.
Technical skills Highly developed organizational skills.
Capacity for teamwork.
Competences Highly developed organizational skills.
Capacity for teamwork.
The Offer – Working Conditions Contract duration: Technical and scientific activities contract linked to the project (estimated until 31/05/2025 with the possibility to extend to 16 months).
Estimated annual gross salary: Salary is commensurate with qualifications and consistent with our pay scales.
We provide a highly stimulating environment with state-of-the-art infrastructures and unique professional career development opportunities.
We offer and promote a diverse and inclusive environment and welcome applicants regardless of age, disability, gender, nationality, ethnicity, religion, sexual orientation, or gender identity.
The CRG is committed to reconciling work and family life of its employees and offers extended vacation periods and the possibility to benefit from flexible working hours.
Application Procedure All applications must include:
Contact details of two referees.All applications must be addressed to Dr. Juan Valcárcel and be submitted online through the "Apply" button below.
Selection Process Pre-selection: The pre-selection process will be based on qualifications and expertise reflected in the candidates' CVs. It will be merit-based.
Interview: Preselected candidates will be interviewed by the Hiring Manager of the position and a selection panel if required.
Offer Letter: Once the successful candidate is identified, the People department will send a Job Offer, specifying the start day, salary, working conditions, among other important details.
Deadline: Please submit your application by September 6, 2024.
This offer has received funding from the European Union's HORIZON-EIC-2021-TRANSITIONOPEN program under grant agreement No 10105805.
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