The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed of an interdisciplinary, motivated and creative scientific team supported by a flexible and efficient administration and high-end innovative technologies.Please, check out our Recruitment Policy:The RolePrecisionTox is a European funded project aimed at establishing a new, 3Rs-compliant (Replacement, Reduction, Refinement), cost-effective testing paradigm for chemical safety assessment — Precision Toxicology. This project revolutionises regulatory toxicology, replaces animal testing, reduces uncertainty, and determines safety factors in assessing risks to human health.This goal will be accomplished by identifying molecular key event (KE) biomarkers predictive of chemically induced adverse health effects in humans. These biomarkers will feed directly into regulatory and industry practice via the systematic use of distantly related animal species from across the tree of life and the highly interdisciplinary mix of genomics, metabolomics, evolutionary theory, quantitative genetics, data science, toxicology, and law.Within this project, our group at the CRG focuses on the analysis of bulk and single cell RNA-seq from five different model species (Danio, Xenopus, Caenorhabditis, Daphnia, and Drosophila), human cell lines, and organoids after treatment with selected putative cardio, neuro, and hepatotoxic compounds emerging from other efforts within PrecisionTox.Our aim is to employ existing and develop novel computational approaches to assess the impact of the chemical compounds on gene expression or co-expression networks across the model species and explore their predictive potential for human toxicity assessment. This project fits within the larger goal of developing methods to relate genome to phenome across the tree of life.About Guigo's LabThe overarching theme of the research in our lab is the understanding of the information encoded in genomic sequences and how this information is processed in the pathway leading from DNA to protein sequences. We are particularly interested in the epigenetic regulation of gene expression and RNA processing, the relationship between molecular phenotypes and higher order endophenotypes and organismal phenotypes, and the identification of functional regions on the genome of all living beings.Our group is mostly computational, focusing on large-scale data analysis and method development, but it also has an important experimental component. We participate in many large-scale international functional genomics projects, such as ENCODE, GTEx, BluePrint, and others.
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