.Post-Doctoral Researcher PrecisionToxThe InstituteThe Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end and innovative technologies. In April 2021, the Centre for Genomic Regulation (CRG) received the renewal of the 'HR Excellence in Research' Award from the European Commission. This is a recognition of the Institute's commitment to developing an HR Strategy for Researchers, designed to bring the practices and procedures in line with the principles of the European Charter for Researchersand theCode of Conduct for the Recruitment of Researchers (Charter and Code). Please, check out our Recruitment PolicyThe rolePrecisionTox is an European funded project, the overarching aim of which is to establish a new, 3Rs- compliant (Replacement, Reduction, Refinement), cost-effective testing paradigm for chemical safety assessment — Precision Toxicology — that revolutionises regulatory toxicology, replaces animal testing, reduces uncertainty, and determines safety factors in assessing risks to human health. This goal will be accomplished by identifying molecular key event (KE) biomarkers, predictive of chemically induced adverse health effects in humans, that feed directly into regulatory and industry practice via the systematic use of distantly related animal species from across the tree of life and the highly interdisciplinary mix of genomics, metabolomics, evolutionary theory, quantitative genetics, data science, toxicology, and law. Within this project, our group at the CRG focuses on the analysis of bulk and single cell RNA-seq from five different model species (Danio, Xenopus, Caenorhabditis, Daphnia and Drosophila),human cell lines and organoids after treatment with selected putative cardio, neuro, and hepatotoxic compounds emerging from other efforts within PrecisionTox. Our aim is to employ existing and develop novel computational approaches to assess the impact of the chemical compounds on gene expression or co-expression networks across the model species and explore their predictive potential for human toxicity assessment. This project fits overall within a larger overarching goal in our group of developing methods to relate genome to phenome across the tree of life. We are searching for a talented post-doctoral researcher with a strong computational background to join the group.About the lab The overarching theme of the research in our lab is the understanding of the information encoded in genomic sequences, and how this information is processed in the pathway leading from DNA to protein sequences
