Organisation/Company: Centre for Genomic Regulation
Research Field: Biological sciences » Other
Researcher Profile: First Stage Researcher (R1)
Positions: Bachelor Positions
Country: Spain
Application Deadline: 4 Dec 2024 - 23:59 (Europe/Madrid)
Type of Contract: Other
Job Status: Full-time
Hours Per Week: 40
Offer Starting Date: 4 Dec 2024
Is the job funded through the EU Research Framework Programme? Horizon 2020
Reference Number: 964342
Is the Job related to staff position within a Research Infrastructure? No
Offer Description The Institute
The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed of an interdisciplinary, motivated, and creative scientific team supported by efficient administration and high-end innovative technologies.
We are looking for a highly motivated Lab Technician with expertise in managing the day-to-day operations of a molecular and cell biology laboratory. This individual will support the lab's research activities and ensure the smooth functioning of lab operations, such as overseeing inventory management and procurement of reagents, consumables, and equipment. He/she will also handle and compile some laboratory procedures, including laboratory ethical procedures. He/she will work closely with other team members to develop and implement research protocols, maintain laboratory compliance, and assist in experimental work in molecular and cellular biology. Ideally, he/she will have experience with mouse handling.
About the lab
In our group, we are investigating the mechanisms controlling the reprogramming of somatic cells, aiming to determine if this reprogramming contributes to tissue regeneration in higher vertebrates.
Differentiation from zygotes has been considered a unidirectional route in all cells of the body. Recently, however, it has become clear that the reverse path is also possible: the reprogramming of somatic nuclei, i.e., the de-differentiation of somatic cells into pluripotent stem-like cells. To date, reprogramming has been induced in vitro by transferring somatic nuclei into enucleated oocytes, by fusing embryonic stem cells (ESCs) with somatic cells, and by transferring specific factors into different types of somatic cells.
Whether reprogramming can occur in vivo in higher vertebrates and what the molecular mechanisms and genes driving reprogramming remain to be defined. We have recently shown that activation of the Wnt/ß-catenin signalling pathway enhances reprogramming of somatic cells after their fusion with ESCs. Remarkably, the activation of this signalling pathway also controls regeneration in response to damage in lower and higher vertebrates; furthermore, cell fusion is one possible mechanism of regeneration in vertebrates. Our main goal is to determine whether in mice activation of Wnt/ß-catenin signalling controls tissue regeneration by enhancing cell-fusion-mediated reprogramming.
Qualifications You have experience in lab management and basic methods in cell and molecular biology.
You are willing to work with multiple species, including humans and pigs.
Desirable but not required:
You have some experience in mouse colony handling.
Languages:
You are fluent in English.
Education and Training:
You hold a Bachelor's or Master's degree in Cell Biology, Molecular Biology, Biotechnology, or a related field.
Technical Skills:
You have advanced MS Office skills.
Competences:
Highly developed organizational skills.
Ability to work in a team with multiple scientists.
Flexibility to be involved in multiple projects.
The Offer – Working Conditions:
Contract duration: 3 months with the possibility of long-term extension.
Estimated annual gross salary: Salary is commensurate with qualifications and consistent with our pay scales.
Target start date: as soon as possible.
We provide a highly stimulating environment with state-of-the-art infrastructures and unique professional career development opportunities. To check out our training and development portfolio, please visit our website in the training section.
We promote a diverse and inclusive environment and welcome applicants regardless of age, disability, gender, nationality, ethnicity, religion, sexual orientation, or gender identity.
The CRG is committed to reconciling work and family life for its employees, offering extended vacation periods and the possibility of flexible working hours.
Application Procedure:
All applications must include:
A motivation letter addressed to Dr. Pia Cosma.
Pre-selection: The pre-selection process will be based on qualifications and expertise reflected in the candidates' CVs. It will be merit-based.
Interview: Preselected candidates will be interviewed by Dr. Pia Cosma.
Offer Letter: Once the successful candidate is identified, the People department will send a Job Offer, specifying the start day, salary, working conditions, among other important details.
Deadline: Please submit your application by December 4th, 2024.
This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 964342.
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