Laboratory Technician - Reprogramming and Regeneration Lab The Institute
The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed of an interdisciplinary, motivated and creative scientific team supported by a flexible and efficient administration and high-end, innovative technologies.
We are looking for a highly motivated Lab Technician with expertise in managing the day-to-day operations of a molecular and cell biology laboratory. This individual will support the lab's research activities and ensure the smooth functioning of lab operations, such as overseeing inventory management and procurement of reagents, consumables, and equipment. He/she will also handle and compile some laboratory procedures, including laboratory ethical procedures. He/she will work closely with other team members to develop and implement research protocols, maintain laboratory compliance, and assist in experimental work in molecular and cellular biology. Ideally, he/she will have experience with mouse handling.
About the lab
In our group, we are investigating the mechanisms controlling the reprogramming of somatic cells, aiming to determine if this reprogramming contributes to tissue regeneration in higher vertebrates.
Differentiation from zygotes has been considered a unidirectional route in all cells of the body. Recently, however, it has become clear that the reverse path is also possible: the reprogramming of somatic nuclei, i.e., the de-differentiation of somatic cells into pluripotent stem-like cells. To date, reprogramming has been induced in vitro by transferring somatic nuclei into enucleated oocytes, by fusing embryonic stem cells (ESCs) with somatic cells, and by transferring specific factors into different types of somatic cells.
Whether reprogramming can occur in vivo in higher vertebrates and what the molecular mechanisms and genes driving reprogramming remain to be defined. We have recently shown that activation of the Wnt/ß-catenin signalling pathway enhances reprogramming of somatic cells after their fusion with ESCs. Remarkably, the activation of this signalling pathway also controls regeneration in response to damage in lower and higher vertebrates; furthermore, cell fusion is one possible mechanism of regeneration in vertebrates. Our main goal is to determine whether in mice activation of Wnt/ß-catenin signalling controls tissue regeneration by enhancing cell-fusion-mediated reprogramming.
Requirements
You have experience in lab management and basic methods in cell and molecular biology.
You are willing to work with multiple species, including humans and pigs.
Desirable but not required
You have some experience in mouse colony handling.
Languages
You are fluent in English.
Education and training
You hold a Bachelor's or Master's degree in Cell Biology, Molecular Biology, Biotechnology, or a related field.
Technical skills
You have advanced MS Office skills.
Competences
Highly developed organizational skills.
Ability to work in a team with multiple scientists.
Flexibility to be involved in multiple projects.
The Offer – Working Conditions
Contract duration: 3 months with the possibility of long-term extension.
Estimated annual gross salary: Salary is commensurate with qualifications and consistent with our pay scales.
Target start date: as soon as possible.
We provide a highly stimulating environment with state-of-the-art infrastructures and unique professional career development opportunities.
We offer and promote a diverse and inclusive environment and welcome applicants regardless of age, disability, gender, nationality, ethnicity, religion, sexual orientation, or gender identity.
The CRG is committed to reconciling a work and family life of its employees and offers an extended vacation period and the possibility to benefit from flexible working hours.
Application Procedure
All applications must include:
A motivation letter addressed to Dr. Pia Cosma.
Contact details of two referees.
All applications must be addressed to Dr. Pia Cosma and submitted online through the "Apply" button below.
Selection Process
Pre-selection: The pre-selection process will be based on qualifications and expertise reflected in the candidates' CVs. It will be merit-based.
Interview: Preselected candidates will be interviewed by Dr. Pia Cosma.
Offer Letter: Once the successful candidate is identified, the People department will send a Job Offer, specifying the start day, salary, working conditions, among other important details.
Deadline: Please submit your application by December 4th, 2024.
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