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MissionTasks and ResponsibilitiesIn collaboration with senior/principal scientists in the team, identify, evaluate, and probe emerging methods for immune cell isolation, culture, differentiation, and activation.Design, execute, interpret, and optimize in vitro assays that can encompass multi-parameter flow cytometry, qRT-PCR, JESS, proliferation, and immunoassays, in order to profile hit, lead and clinical molecules.In collaboration with senior/principal scientist in the team, design and optimize state-of-the-art experimental protocols for gene modulation and cell line/primary cell engineering, including RNA interference, stable transfection and CRISPR-Cas9 mediated gene editing, in order to study signalling pathways of interest.Independently analyse experimental results, and present data analysis and plans at cross-functional meetings.EducationMSc with 1+ years of experience or PhD in Immunology, Molecular Biology or Cellular Biology.Specific KnowledgeExperience in cell culture. Experience with primary immune cells (PBMC, lymphocytes…) or with skin cells such as primary keratinocytes.Theoretical and experimental background in cellular assays such as flow cytometry, ELISA, HTRF, qPCR, WB. Experience with functional immunology assays (e.g. PBMC activation, MLRs) and spectral flow cytometry would be a plus.Experience with gene modulation assays (siRNA and plasmids transfection, lentiviral transduction of shRNA…) would be a plus.Interest in new therapeutic modalities such as bispecific antibodies, Targeted Protein Degradation, cell or mRNA therapies would be a plus.Excellent organization skills and track record for generation of high data quality.Track record of continual growth, curiosity, and drive to learn.Team player with ability to collaborate and communicate effectively across several scientific disciplines.Advanced English level required.ValuesCare: we listen & empathize, we value diverse perspectives & backgrounds and we help each other succeed.Courage: we challenge the status quo, we take full ownership and we learn from our success & failures.Innovation: we put the patient and customer at the center, we create novel solutions and we empower entrepreneurial mindsets.Simplicity: we act decisively and avoid over-analysis, we understand why before we act and we are agile & keep things simple.
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