(Inicio Inmediato) Phd Position: Understanding The Genetic Basis Of Tumorigenesis

.- You are here:Home > PhD Position: Understanding the genetic basis of tumorigenesisPhD Position: Understanding the genetic basis of tumorigenesisPhD Position: Understanding the genetic basis of tumorigenesisThe InstituteThe Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end and innovative technologies.We are looking for a PhD student candidate to join the 'Evolutionary Processes Modeling' group. The ideal candidate should be highly motivated and eager to work on evolutionary and biological problems and to learn about the use and development of computational, statistical and machine learning approaches.The GroupCancer is a genetic disease, subject to population genetics forces like mutation, selection and stochasticity. Our group is particularly interested in how the evolution and survival of cancer cell populations relies on mutation influx and in how we can identify cancer driver events from observed mutation data. To this end, we develop mathematical and computational approaches to estimate mutation rates, tumor growth dynamics and selection. Analysis of the mutational processes acting in cancer genomes allows us to learn about carcinogenic mutagens ( https://www.Biorxiv.Org/content/10.1101/2023.12.06.570467v1 ), while studying the spatial genetic heterogeneity of tumors tells us about the tumor mode of growth ( https://www.Biorxiv.Org/content/10.1101/2023.12.10.570995v1 ). Estimates of the strength of selection in cancer allow a prioritization of genes and non-coding regions by their disease relevance, with the ultimate goal of promoting therapeutic advances. Coding sequences of cancer tumors not only exhibit positively selected mutations that drive cancer ( www.Nature.Com/articles/s41588-019-0572-y ), but there also exists a small fraction of genes that the tumor cannot afford to lose ( www.Nature.Com/articles/ng.3987 ). In addition to genes, cancer driver loci can occur in the non-coding part of the genome ( www.Nature.Com/articles/s41467-017-00100-x ).We are looking for a PhD student to join the lab to help elucidate cancer evolutionary dynamics using population genetics predictions and simulations together with published and unpublished cancer sequencing data. Research interests within the field of population genetics but outside this specific topic will also be considered