Deadline: 23/11/2024Centre / Institution: Center for Genomic RegulationThe InstituteThe Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed of an interdisciplinary, motivated and creative scientific team supported by a flexible and efficient administration and by high-end and innovative technologies.We are seeking a Biocatalyst, Biochemist, or Protein Engineer to lead the experimental testing and optimization of enzymes generated by our AI models.ResponsibilitiesThe candidate will be responsible for high-throughput screening and directed evolution approaches to manage and evaluate thousands of enzymes efficiently. This role is vital to experimentally validate in a high-performance fashion the predictions made by our AI models, and the feedback will be crucial to improve the models over time. The candidate will learn cutting-edge AI techniques and will focus on the engineering of biotechnologically relevant enzymes.About the labThe candidate will join an interdisciplinary research group at the forefront of AI-driven protein design and engineering. The team is highly collaborative, integrating computational scientists, experimental biologists, and biotechnologists to push the boundaries of synthetic biology and protein engineering.Desired skills and expertiseMust Have:You have 3+ years of experience in protein engineering, specifically in the testing of enzyme variants.Wide experience in the implementation and screening of enzyme activity assays.You have familiarity with directed evolution techniques and (ultra)-high throughput techniques.You are fluent in English and possess strong communication skills.Desirable but not required/ Nice to have:Experience with robotic liquid-handling platforms for high-throughput workflows and automation.Willingness to learn about machine learning methods for protein engineering and design.Education and trainingYou hold or are about to defend a PhD in Biochemistry, Chemistry, Molecular Biology, Biotechnology, or a related field.LanguagesYou are proficient in English.Technical skillsYou have advanced skills in protein engineering techniques, such as mutagenesis, cell-free systems, and/or (ultra-) high-throughput assays.You can independently develop protocols to screen the activity, selectivity, and thermodynamics of enzyme variants.Experience automating systems for handling and screening thousands of protein variants.CompetencesA passion for working in a high-paced, AI-driven research environment and the willingness to adapt and implement cutting-edge technologies. Highly developed organizational skills to manage high-throughput experimental workflows and data, capable of working at agile paces. Strong problem-solving abilities, with a proactive and innovative mindset.#J-18808-Ljbffr