Your mission The Josep Carreras Leukaemia Research Institute (IJC) is a non-profit research institute based in Barcelona dedicated to advancing the understanding of leukemia and related disorders, in collaboration with the University of Barcelona and the Autonomous University of Barcelona.The IJC has laboratories in 5 clinical campuses: i) Hospital Clínic, ii) Hospital de Sant Pau, iii) Hospital Germans Trias Pujol, iv) Hospital del Mar, and v) Hospital Josep Trueta Girona.IJC serves as a collaborative center for basic researchers and physicians to work together on fundamental clinical and biological aspects of leukemia.The IJC offers an excellent work environment based on a multidisciplinary fusion of state-of-the-art ideas and facilities.For further information, please visit our webpage: http://www.carrerasresearch.org/en and the Josep Carreras nonprofit organization: https://www.fcarreras.org/en .Leukemia and immuno-oncology research group, led by Dr. Laura Belver, is looking for a motivated Laboratory Technician.Research description SHP2 inhibition has emerged as a promising therapeutic strategy, leading to the development of allosteric SHP2 inhibitors that have shown encouraging results in ongoing clinical trials.However, a significant drawback of these molecules is their inability to inhibit SHP2 mutant forms, such as those found in hematologic malignancies and, less frequently, in some solid tumors.In this context, our lab has identified six novel compounds that exhibit efficient inhibitory effects on both wild type and mutant SHP2.The main goal of this project is to conduct a comprehensive preclinical evaluation of the therapeutic potential of these new SHP2 inhibitors by studying their spectrum of action, physicochemical properties, pharmacokinetics, and therapeutic effects on hematologic and solid tumors.For more information, visit our lab websites: https://www.carrerasresearch.org/en/research/leukemia-and-immuno-oncology and https://belverlab.org/ .Main responsibilitiesThe candidate person will perform tasks for the development of experimental therapeutics research.These tasks will include the implementation of experimental methods in molecular biology and biochemistry, the execution of in vitro assays using both established cell lines and primary cells, the use of specialized analytical systems such as flow cytometry, and the design and execution of in vivo mouse experiments.The candidate will also be expected to handle laboratory management duties.Your profile Must haveAt least three years of experience as a lab technician performing molecular biology and biochemistry techniques, and laboratory management dutiesExperience in the use of flow cytometryFELASA accreditation for animal experimentation and at least three years of experience working with mice as experimental models (mandatory)Fluent in spoken EnglishOther requirementsAbility to work collaboratively with others on research projectsIt will be positively evaluated if the experience has previous experience in leukemia researchWhy us?Contrato indefinido por actividades científico-técnicas linked to PID2023-148276OB-I00, funded by MCIU/AEI/10.13039/501100011033 and el FSE+.Be part of a young, collaborative, and international work environment with cutting-edge technologies and interdisciplinary teams of scientists, including experts in medicine, immunology, genomics, and bioinformatics.An exciting and innovative research project.The stimulating environment of the Barcelona metropolitan area.Deadline Please submit your application by August 21st, 2024.About usWhat makes us different?The mission of the Josep Carreras Institute is to conduct research and drive innovation in the epidemiological, preventive, clinical, translational, and basic aspects of cancer, with a special emphasis on leukemia and other hematologic malignancies, with the final aim of finding a cure for these diseases.The IJC's vision is to be a world-class reference and excellent research multicampus that contributes to the improvement of results, and the cure of patients affected by leukemia and other malignant hemopathies, through innovation, sustainability, social responsibility, talent, and professional experience.The IJC is an equal opportunity employer.We evaluate qualified applicants without regard to race, color, religion, sex, national origin, disability, or other legally protected characteristics.
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