Bioinformatics Postdoc – Gencode Project

.The InstituteThe Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed by an interdisciplinary, motivated and creative scientific team which is supported both by a flexible and efficient administration and by high-end and innovative technologies.In April 2021, the Centre for Genomic Regulation (CRG) received the renewal of the 'HR Excellence in Research' Award from the European Commission. This is a recognition of the Institute's commitment to developing an HR Strategy for Researchers, designed to bring the practices and procedures in line with the principles of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers (Charter and Code).Please, check out our Recruitment PolicyThe roleOur group is involved in the GENCODE project (www.Gencodegenes.Org), which aims to provide a high-quality, comprehensive map of genes and regulatory elements in the human and mouse genomes. Within this framework, the Guigó lab is responsible for producing high-quality transcriptome sequencing data for the consortium, with the goal of improving the annotation of long noncoding RNA (lncRNA) genes. To achieve this, our experimental group applies cutting-edge targeted long-read RNA sequencing methods such as CLS (Capture Long-Seq), a technique we developed at the CRG (doi: 10.1038/ng.3988).We are searching for a talented post-doctoral researcher with a strong computational background to join the group. Your role will be to collaborate closely with our experimental team to help optimize protocols, conduct quality control, and develop analysis pipelines. Additionally, a significant component of the post-doc's role will involve tackling fundamental biological questions related to the role of lncRNAs in mammalian biology. Specifically, we are interested in the discovery and characterization of novel transcriptional elements that have previously escaped detection but can be accessed through CLS.About the labThe overarching theme of the research in our lab is the understanding of the information encoded in genomic sequences, and how this information is processed in the pathway leading from DNA to RNA and protein sequences. More specifically, we are interested in the epigenetic regulation of gene expression and RNA processing, the relationship between molecular phenotypes and higher-order endophenotypes and organismal phenotypes, and the identification of functional regions on the genome of all living beings. Our group is mostly computational, and we do both large scale data analysis and development of methods, but it has also an important experimental component. We are past and current members of many large scale international functional genomics projects, such as ENCODE, GTEx, BluePrint and others