07 oct | Instituto De Salud Global De Barcelona (Isglobal) | Barcelona
Bioinformatician for the PREDIMED-Plus RCT The Barcelona Institute for Global Health (ISGlobal) is a cutting-edge institute addressing global public health challenges through research, translation into policy and education. ISGlobal has a broad portfolio in communicable and non-communicable diseases including environmental and climate determinants, and applies a multidisciplinary scientific approach ranging from the molecular to the population level.
ISGlobal is seeking a bioinformatician who is interested in taking over and managing activities of the project PREDIMED-Plus RCT during 3 months. The project aims to prospectively assess the association between a wide range of environmental exposures and body composition in adults with overweight/obesity and metabolic syndrome from the PREDIMED-Plus RCT.
Specific body composition components seem to be the key to the development of obesity-associated chronic diseases. In particular, excess visceral fat and loss of muscle mass, which occurs with increasing age, but also with unhealthy lifestyle patterns, have been associated with a higher risk for a broad spectrum of health outcomes including cardiovascular disease and type 2 diabetes.
The recent study performed in the PREDIMED-Plus randomized controlled trial (RCT) demonstrated that the lifestyle intervention based on an energy-restricted Mediterranean diet and physical activity significantly reduced grams of visceral fat and percentage of total fat mass and increased percentage of lean mass at 3 years of follow-up of older adults with metabolic syndrome.
Moreover, we also found that replacing sedentary time with physical activity at low intensities might be an appealing strategy for older adults to improve body composition (fat and muscle mass). Besides individual lifestyle habits (diet and physical activity), many other environmental exposures from the external exposome (such as air pollution, noise, built environment characteristics, etc) might also elicit an effect on body composition.
In the current study, we seek to evaluate the potential role of these external exposome factors in the intervention effects over PREDIMED-Plus participants.
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