.Do you feel passionate about the possibilities of great science changing the lives of cancer patients? Do you have a background in oncology and/or translational research and an interest in working with antibody drug conjugates (ADCs)? If so, this may be the role for you.We currently have an exciting opportunity for a highly motivated Associate Director/Director to join our team of translational medicine leads supporting our internal ADC programs.ABOUT ASTRAZENECAAstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development, and commercialization of prescription medicines for some of the world's most serious diseases. Within AstraZeneca Oncology R&D, we are committed to advancing the science to deliver life-changing medicines to patients most in need.The Translational Medicine function exists within AstraZeneca R&D to ensure effective and strategic biomarker studies for Oncology project teams. The Translational Medicine team is the single point of accountability for delivery of robust, scientifically-driven biomarkers to all project teams, providing feasibility assessments, technical validation, and centralized biomarker analysis capability for clinical samples.What you'll do/Job descriptionWe are seeking an Associate Director/Director in Oncology Translational Medicine Strategist to develop biomarker strategies and ensure delivery within our internal ADC oncology project portfolio teams.Working in partnership with the Translational Medicine team, lead the implementation of strategic vision that enables indication selection, early indication of biological activity, and patient stratification/selection in Oncology.ResponsibilitiesDelivering translational science and biomarker strategies for early and late development oncology assets through Ph1 to Ph 3 clinical studies based on the best available science and technologies.Generating disease linkage data to guide indication selection and targeted patient populations.Measuring target engagement and pharmacodynamic biomarkers reliably and quantifiably to advise clinical decisions for selecting therapeutically relevant doses and schedules.Understanding key cancer pathway interactions, feedback mechanisms, and features of tumor microenvironment in clinical samples to guide rational drug combinations.Defining novel mechanisms of resistance targeted therapies by studying tumors at relapse.Influence translational strategy across the AZ portfolio.Collaborate with Oncology Research, Translational Medicine, and product development teams to facilitate appropriate incorporation of Translational Medicine strategies for molecules in early to late development in Oncology.Collaborate with clinical operations and clinical teams to define sample collection, lab manuals and clinical study protocols, and biomarker analyses in clinical studies related to oncology
