.The Vall d´Hebron Institute of Oncology (VHIO) Seeks a Postdoctoral Researcher Reference: 2024-070-01 Application deadline: Until filled Number of vacancies: 1 Job description: The TETRIS project (Risk assessment tools for severe side Effects after Breast Radiotherapy: radiation safety through biological extended models and Digital Twins ) is a cutting-edge European research initiative funded under the HORIZON-EURATOM-2023-NRT-01-10 program.
The project aims to develop and test quantitative, personalized risk scores for radiotherapy-induced side effects.
These scores are based on dose-response relationships published in the literature and further refined by integrating patient-specific data, including imaging, genetics, and transcriptomics.
TETRIS also seeks to explore the potential of using digital twins (DTs) in radiotherapy safety.
By leveraging data from historical patient cohorts, the project will create prototype DTs and evaluate the benefits of this approach compared to traditional model-based risk scores.
A prospective collection of detailed patient data will enable the refinement of DTs, offering both a deeper understanding of individual patients and broader insights into follow-up care.
The refined DTs could drive future investments in data collection and computational infrastructure for radioprotection.
Joining TETRIS provides an exciting opportunity to be part of a dynamic and interdisciplinary team with a strong track record of collaboration.
It offers involvement in translational and clinical research projects at the forefront of Radiogenomics and personalized medicine.
For more information about the team and their research, please visit: Key Responsibilities: Develop polygenic risk scores using both genotyping arrays and whole-genome sequencing (WGS) data.
Analyse massively sequencing data to identify and assess clonal haematopoiesis.
Collaborate closely with clinical and computational teams to generate the clinical and genomic datasets required for the project.
Oversee and monitor the proper collection of patient samples and ensure accurate completion of project questionnaires.
Present research findings at national and international conferences and contribute to impactful scientific publications.
Requirements: Essential Qualifications: PhD in genetics, bioinformatics, or a related discipline.
Proven experience analysing genomic data, particularly from whole-genome sequencing and targeted sequencing.
Familiarity with genome-wide association study (GWAS) analyses.
Ability to work effectively in an interdisciplinary team environment.
Strong level of organization and a proactive character.
Proficiency in English (both written and spoken).
Valuable Qualifications: Experience in managing European research projects.
Hands-on experience with genetics laboratory workflows and clinical data management.
Fluency in Spanish and Catalan