Your mission The Josep Carreras Leukemia Research Institute (IJC) is a comprehensive cancer research center dedicated to researching and promoting innovation in the epidemiological, preventive, clinical, translational and basic aspects of leukemia and other hematological malignancies, with the objective end of finding a cure for these diseases.
It was created in 2010, and since then, it has experienced exponential growth.
The IJC is also part of the network of Research Centers of Excellence of Catalonia (CERCA) and was accredited as a Severo Ochoa Center of Excellence by the Ministry of Science, Innovation and Universities in 2024.
Since 2018, the Institute has also been accredited by the Scientific Foundation of the Spanish Association Against Cancer (FCAECC) In addition, the IJC is one of the centers integrated into the accreditation of the Germans Trias i Pujol Research Institute (IGTP) as an Accredited Health Research Institute (IIS) by the Health Institute Charles III (ISCIII).
The IJC main headquarters is located within the Can Ruti Biomedical Campus, together with other leading biomedical institutions, providing direct access to cutting-edge scientific and technological facilities, as well as complementary community services.
The IJC has six headquarters integrated into reference hospitals: Hospital Germans Trias i Pujol, Hospital Clínic, Hospital Sant Pau, Hospital Trueta, Hospital del Mar and Hospital San Joan de Déu.
This facilitates close collaboration between basic and clinical researchers, fostering translational research that integrates basic science with clinical practice in clinical settings.
We are seeking a LABORATORY TECHNICIAN for our institute.
RESEARCH DESCRIPTION The main goal of the Stem cell biology, developmental leukemia and immunotherapy, led by Dr. Pablo Menéndez, is to investigate and understand the pathogenic mechanisms and cell-of-origin of pediatric leukemias and developing novel adoptive immunocellular therapies based on the use of CAR T-cells.
Our group is interested in understanding the cellular origin, etiology and pathogenesis of childhood leukemia.
We aim to ascertain the cell in which mutations occur and we strive to discover which cells are responsible for triggering relapses.
Furthermore, we work to identify new therapeutic targets and develop more targeted, less toxic therapies.
To achieve this, our laboratory uses various approaches, including genetic studies, epigenetic techniques and animal models, as well as adoptive cell immunotherapy tools.
This contract is linked to the project PRYGN234975MENE, Next generation, off-the-shelf, CD1a/CCR9-directed dual CAR immunotherapy for relapse/refractory T-cell acute lymphoblastic leukemia MAIN RESPONSIBILITIES Mouse colony managing and breeding of immunodeficient colony (including NSG and NSGS strains).
Co-design, in close collaboration and communication with the researchers of the group, in vivo experimental procedures and experiments.
Supervise the development and evolution of the experiments.
Substance administration by various routes.
This inludes administration such as intraperitoneal, intravenous, subcutaneous, intratibial, intrahepatic, oral gavage, etc.
Blood sampling from sub-mandibular and intracardiac.
Mouse biopsy and genotyping.
Mouse bone marrow aspirates.
In vivo imaging techniques including bioluminescence.
Mouse euthanasia and tissue sampling.
Animal welfare supervision.
Train other researchers and give technical support to collaborators of the group.
Implement and discuss the standard operating procedures for animal experimentation with the members of the group.
Assist in writing procedures and protocols for the Animal Ethics Experimentation Committee.
Your profile WHAT WE NEED Accreditation according to R.D 53/2013 for the functions a) animal care, b) euthanasia of animals, c) performance of procedures, d) design of projects and procedures and e) assumption of responsibility for on-site supervision of animal welfare and care.
Solid experience in mouse handling, breeding, and welfare supervision.
Experience with immunodeficient mice, patient-derived xenografts, and cancer models for disease initiation and treatment.
Ability to design experiments and discuss them openly with other researchers in the team and external collaboration.
A command of molecular biology/biochemistry, haemocytometer, flow cytometry analysis skills and cell culture knowledge is not mandatory but would be a plus.
Knowledge on hematopoiesis, leukemia or immunotherapy.
Team player, very high standard of organization and communication is mandatory.
Eager to learn and contribute to preclinical research in the field of acute leukemia.
Why us?
WHAT WE OFFER This contract is linked to the project PRYGN234975MENE, Next generation, off-the-shelf, CD1a/CCR9-directed dual CAR immunotherapy for relapse/refractory T-cell acute lymphoblastic leukemia The stimulating environment of the Barcelona metropolitan area.
Participation in innovative and multidisciplinary projects.
Opportunity for professional growth in an advanced research environment.
Working in the basic laboratory with strong collaborations with clinical researchers in the environment of the Josep Carreras Leukaemia Research Institute.
Deadline DEADLINE FOR APPLICATIONS ? Please submit your application by 17/12/2024 About us What makes us different?
The mission of the Josep Carreras Institute is to conduct research and drive innovation in the epidemiological, preventive, clinical, translational, and basic aspects of cancer, with a special emphasis on leukaemia and other hematologic malignancies, with the final aim of finding a cure for these diseases.
The IJC's vision is to be a world-class reference and excellent research multicampus that contributes to the improvement of results, and the cure of patients affected by leukemia and other malignant hemopathies, through innovation, sustainability, social responsibility, talent, and professional experience.
HR Excellence In 2019, IJC was honored with the "Human Resources Excellence in Research Award" by the European Commission, recognizing the alignment of our human resources policies with the European Charter for Researchers and Code of Conduct for the Recruitment of Researchers.
The Human Resources Strategy for Researchers (HRS4R) guides research centers of excellence in implementing and upholding these standards within their policies, emphasizing training, professional development, and mobility opportunities.
The IJC's commitment to these values and principles strengthens our internal policies and ensures that our members have the optimal conditions and environment for their professional development.
The IJC is an equal opportunity employer.
We evaluate qualified applicants without regard to race, color, religion, sex, national origin, disability, or other legally protected characteristics.