The Institute The Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed of an interdisciplinary, motivated and creative scientific team supported by a flexible and efficient administration and by high-end and innovative technologies.
In April 2021, the Centre for Genomic Regulation (CRG) received the renewal of the 'HR Excellence in Research' Award from the European Commission. This is a recognition of the Institute's commitment to developing an HR Strategy for Researchers, designed to bring the practices and procedures in line with the principles of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers (Charter and Code).
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The role The successful candidate will address a critical question in mechanobiology: how mechanical forces relate to nuclear RNA-processing organelles (biomolecular condensates) in health and/or disease? Using interdisciplinary approaches, the candidate will explore how cytoskeletal forces impact nuclear dynamics across scales, from organelle remodeling down to RNA-processing regulation, and how this physical link influences cell division.
About the team/lab/department Group leaders: Adel Al Jord, PhD & Verena Ruprecht, PhD
A prominent research focus of the Al Jord Lab is the relation between physical forces and the remodeling of essential nuclear RNA-processing organelles known as biomolecular condensates. We pioneered in revealing that, in germ cells, cytoskeletal forces mechanically remodel and regulate nuclear condensates across scales for reproductive success. Whether somatic cells, which compose the majority of cells in an organism, evolved this mechanical mechanism of organelle remodeling remains a mystery. However, our new evidence indicates that this mechanism is deployed by mammalian somatic cells within diverse physiological and pathological contexts. We therefore aim to venture into these unexplored grounds of nuclear condensate mechano-regulation across somatic cell types in health and disease. The research objective is to decipher how cytoskeletal forces impact nuclear dynamics across scales, from organelle remodeling down to RNA-processing regulation, and how this physical link influences somatic cell division and specialization. To attain this aim, our research follows a cross-disciplinary approach, bridging methods from systems, cell, molecular, and synthetic biology along with computational and biophysical tools. This comprises techniques like protein multiplexing, advanced imaging, optogenetics, and force measurement and modulation assays.
Whom would we like to hire? Professional experience Must Have The candidate must hold a PhD, preferably in Cell & Molecular Biology, Oncology, or Biophysics.
Lab experience with mammalian cell culture and common techniques in Cell & Molecular biology.
Experience with advanced imaging and image analyses.
Desirable but not required/Nice to have Experience with transcriptomics.
Languages Fluency in English.
Computer skills Advanced MS Office and Prism experience.
Skilled with image and data analyses software.
Competences Rigor, organization, and autonomy.
Strong analytical, interpersonal, and communication skills.
Curiosity and critical thinking.
The Offer – Working Conditions Contract duration: Technical and scientific activities contract linked to the project - estimated 18 months with extension possibility.
Estimated annual gross salary: Salary is commensurate with qualifications and consistent with our pay scales.
Target start date: November 2024.
We provide a highly stimulating environment with state-of-the-art infrastructures and unique professional career development opportunities. To check out our training and development portfolio, please visit our website in the training section.
We offer and promote a diverse and inclusive environment and welcome applicants regardless of age, disability, gender, nationality, ethnicity, religion, sexual orientation or gender identity.
The CRG is committed to reconciling work and family life of its employees and is offering an extended vacation period and the possibility to benefit from flexible working hours.
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