.Organisation/Company: Centre for Genomic RegulationResearch Field: Biological sciences » OtherResearcher Profile: First Stage Researcher (R1)Positions: Bachelor PositionsCountry: SpainApplication Deadline: 4 Dec 2024 - 23:59 (Europe/Madrid)Type of Contract: OtherJob Status: Full-timeHours Per Week: 40Offer Starting Date: 4 Dec 2024Is the job funded through the EU Research Framework Programme? Horizon 2020Reference Number: 964342Is the Job related to staff position within a Research Infrastructure? NoOffer Description The InstituteThe Centre for Genomic Regulation (CRG) is an international biomedical research institute of excellence, based in Barcelona, Spain, with more than 400 scientists from 44 countries. The CRG is composed of an interdisciplinary, motivated, and creative scientific team supported by efficient administration and high-end innovative technologies.We are looking for a highly motivated Lab Technician with expertise in managing the day-to-day operations of a molecular and cell biology laboratory. This individual will support the lab's research activities and ensure the smooth functioning of lab operations, such as overseeing inventory management and procurement of reagents, consumables, and equipment. He/she will also handle and compile some laboratory procedures, including laboratory ethical procedures. He/she will work closely with other team members to develop and implement research protocols, maintain laboratory compliance, and assist in experimental work in molecular and cellular biology. Ideally, he/she will have experience with mouse handling.About the labIn our group, we are investigating the mechanisms controlling the reprogramming of somatic cells, aiming to determine if this reprogramming contributes to tissue regeneration in higher vertebrates.Differentiation from zygotes has been considered a unidirectional route in all cells of the body. Recently, however, it has become clear that the reverse path is also possible: the reprogramming of somatic nuclei, i.E., the de-differentiation of somatic cells into pluripotent stem-like cells. To date, reprogramming has been induced in vitro by transferring somatic nuclei into enucleated oocytes, by fusing embryonic stem cells (ESCs) with somatic cells, and by transferring specific factors into different types of somatic cells.Whether reprogramming can occur in vivo in higher vertebrates and what the molecular mechanisms and genes driving reprogramming remain to be defined. We have recently shown that activation of the Wnt/ß-catenin signalling pathway enhances reprogramming of somatic cells after their fusion with ESCs. Remarkably, the activation of this signalling pathway also controls regeneration in response to damage in lower and higher vertebrates; furthermore, cell fusion is one possible mechanism of regeneration in vertebrates